The Department of Health and Human Services (HHS) is currently emphasizing AI and IT modernization across multiple agencies, including the CDC, FDA, and HRSA. Recent solicitations highlight a focus on AI integration in enterprise workflow systems and fraud detection platforms, reflecting HHS's push to leverage AI for operational efficiency and data analytics.
Use keywords like "HHS AI RFP" or "Health and Human Services AI solicitation" on federal procurement platforms such as SAM.gov. Focus on solicitations under NAICS codes 541511 (Custom Computer Programming Services) and 541519 (Other Computer Related Services) for relevant AI and IT support opportunities.
The most immediate deadline is June 1, 2026, for the CDC's Customer IT Support services (RFP1810356). Other recent deadlines, such as March 27, 2026 for HRSA's AI/ML fraud detection RFQ, have passed but indicate the typical quarterly cadence of solicitations.
Current solicitations do not explicitly state small business set-asides, but contractors should review each solicitation's specific acquisition strategy. GSA Alliant 2 vehicle solicitations often allow small business participation through subcontracting or specific task orders.
GSA Alliant 2 is a primary vehicle for large-scale IT and AI-related services at HHS, as seen in multiple recent solicitations. Contractors should be familiar with Alliant 2 requirements and how to respond to task orders under this vehicle.
While specific incumbents are not always disclosed, large IT services firms with expertise in AI and federal health IT, such as those supporting CDC and FDA systems, are frequent awardees. Reviewing past awards on FPDS.gov can provide insight into incumbents for these NAICS codes and agencies.
CDC Customer Information Technology Support (CITS) Services Re-solicitation
The Centers for Disease Control and Prevention (CDC) is re-soliciting for comprehensive Customer Information Technology Support (CITS) services to support approximately 28,000 personnel across mult...
CDC Global Health Center Informatics and IT Support Services Solicitation
The Centers for Disease Control and Prevention (CDC), through its Global Health Center and Office of Acquisition Services, is seeking proposals for comprehensive Informatics and IT Support services...
Support and Enhancement Services for openFDA Platform
This opportunity seeks contractor support for the openFDA platform, which provides public FDA data in machine-readable formats for AI and analytics applications. - Government Buyer: - Department ...
FDA Enterprise Workflow Management Systems BPA – Development, Modernization, and AI Integration
The U.S. Food and Drug Administration (FDA), part of the Department of Health and Human Services, is seeking contractor support for the full lifecycle of enterprise-scale workflow management system...
AI/ML Fraud Detection and Management Platform Development for HRSA
The Health Resources and Services Administration (HRSA) Office of Budget and Finance is seeking advanced AI/ML services to develop and support a Fraud Detection and Management Platform (FDMP) for g...
CDC Solicitation for AWS Cloud Capacity and Compute Services (GSA MAS SIN 518210C)
This opportunity from the Centers for Disease Control and Prevention (CDC) seeks AWS cloud computing services for federal operations, with a focus on prepaid consumption credits and consolidated bi...
HRSA BPA for IT Operations, Maintenance, and Data Engineering Services for Data and Web Platforms
The Health Resources and Services Administration (HRSA), part of the U.S. Department of Health and Human Services, is seeking small business sources for a Blanket Purchase Agreement (BPA) to provid...
Procurement of Marketplace System Integrator (MSI) Services for CMS Health Insurance Exchange
This procurement opportunity is for the Centers for Medicare & Medicaid Services (CMS), specifically the Center for Consumer Information and Insurance Oversight (CCIIO) under the Marketplace In...
HRSA's BPA for Software and Cloud Support Systems
The Health Resources and Services Administration (HRSA), operating under the Department of Health and Human Services (HHS), is soliciting contracted services for software development, operational s...
HRSA Software Development and Support Services for Custom Applications and SharePoint Collaboration Solutions
This procurement opportunity is issued by the Department of Health and Human Services (HHS), specifically the Health Resources and Services Administration (HRSA), for comprehensive software develop...
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