Artificial Intelligence Procurement Opportunities at Department of Health and Human Services

The Department of Health and Human Services (HHS) is currently issuing solicitations that emphasize analytic support and IT modernization, particularly within its Centers for Disease Control and Prevention (CDC) and Agency for Healthcare Research and Quality (AHRQ) components. Recent requests for quotations (RFQs) highlight a focus on AI-enabled data analysis and IT security services to support public health surveillance and quality measurement programs.

Market Analysis

Frequently Asked Questions

How can I find current AI-related solicitations from HHS?

You can monitor the General Services Administration (GSA) eBuy platform and the System for Award Management (SAM.gov) using keywords like "HHS AI RFP" or "Health and Human Services AI solicitation." Focus on solicitations under NAICS codes 541511 (Custom Computer Programming Services) and 541519 (Other Computer Related Services).

What are the typical response deadlines for HHS AI procurements?

Recent solicitations have response deadlines clustered in early to late August 2026, with specific dates such as August 6, 10, 12, and 31. It is critical to track each solicitation individually as deadlines vary by project scope.

Are there set-aside requirements for these HHS AI contracts?

The provided opportunities do not explicitly mention small business set-asides or other socio-economic preferences. Contractors should review each solicitation's terms on GSA eBuy or SAM.gov for any applicable set-aside designations.

Which NAICS codes are relevant for HHS AI procurement opportunities?

The primary NAICS codes for these solicitations are 541511 (Custom Computer Programming Services) and 541519 (Other Computer Related Services), covering software development, IT services, and analytic support.

Who are the incumbent contractors or agencies managing these AI procurements?

The CDC and AHRQ are the main HHS agencies issuing these solicitations, with the Office of Mission Acquisition Solutions (OMAS) and the Office of Acquisition Services managing procurement processes. Incumbent contractors are not specified in the current solicitations and should be researched via past contract award notices.

Recent Opportunities

GSA Alliant 2 #RFP1830979

CMS Solicitation for Federal Services Systems Support & Oversight (FSSSO) Program

Department of Health and Human Services Posted August 17, 2026 Respond by September 01, 2026

CMS is seeking contractor support for the Federal Services Systems Support & Oversight (FSSSO) Program, focused on ACA and NSA compliance, technical assistance, and operational support. - Gover...

GSA #RFQ1828358

HHS Solicitation for Welfare Rules Database (WRD) Sustainment, Update, and IT Security Services

Department of Health and Human Services Posted August 07, 2026 Respond by August 31, 2026

The Department of Health and Human Services (HHS), through the Administration for Children and Families (ACF) and the Office of Mission Acquisition Solutions (OMAS), is seeking contractor support f...

GSA #RFQ1826681

CDC HSPD-12 Smart Card and CCURE PACS Integration Services Solicitation

Department of Health and Human Services Posted July 29, 2026 Respond by August 12, 2026

The Centers for Disease Control and Prevention (CDC), under the Department of Health and Human Services, is seeking HSPD-12 Smart Card Services to enhance its Identity and Access Management (IAM) p...

GSA #RFQ1825434

Analytic Support Services for AHRQ Quality Indicators Program

Department of Health and Human Services Posted July 23, 2026 Respond by August 06, 2026

This opportunity seeks analytic support services for the Agency for Healthcare Research and Quality (AHRQ) Quality Indicators (QIs) program. - Government Buyer: - Agency for Healthcare Research a...

GSA #RFQ1821675

CDC Solicits Agile IT Services for NEDSS Base System Modernization and Support

Department of Health and Human Services Posted July 13, 2026 Respond by August 10, 2026

The Centers for Disease Control and Prevention (CDC), through its Office of Public Health Data, Surveillance, and Technology (OPHDST), is seeking a contractor to provide Agile IT services for the m...

GSA #RFQ1820013

CDC Solicits Support Services for National Cancer Registries and Surveillance Systems

Department of Health and Human Services Posted June 26, 2026 Respond by July 24, 2026

The Centers for Disease Control and Prevention (CDC), through its Office of Financial Resources and Office of Acquisition Services, is seeking a contractor to provide comprehensive support services...

GSA #RFP1823266

NIH NLM Software Development, Automation, and Cloud Support Services

Department of Health and Human Services Posted July 14, 2026 Respond by July 29, 2026

The National Institutes of Health (NIH), National Library of Medicine (NLM), Office of Computer and Communications Systems (OCCS) is seeking a contractor for comprehensive software development, aut...

GSA STARS3 #RFP1821407

CMS AI-Enabled Provider Compliance Self-Assessment Tool and Support Services

Department of Health and Human Services Posted July 09, 2026 Respond by July 20, 2026

This opportunity is a multi-year procurement by the Centers for Medicare & Medicaid Services (CMS) to develop and support an AI-enabled provider compliance self-assessment tool for post-acute c...

GSA #RFQ1823324

CDC NeuVector Software License Renewal (72 Licenses, 12-Month Term)

Department of Health and Human Services Posted July 14, 2026 Respond by July 22, 2026

The Centers for Disease Control and Prevention (CDC) is seeking quotes for the renewal of NeuVector software licenses to secure its containerized and Kubernetes-based workloads across multi-cloud e...

GSA #RFQ1817639

CDC Seeks IT Services for Secure HIV-TRACE Application Operations, Modernization, and Support

Department of Health and Human Services Posted June 12, 2026 Respond by July 15, 2026

The Centers for Disease Control and Prevention (CDC), Division of HIV Prevention, is seeking IT professional services for the Secure HIV-TRACE bioinformatics application. - Government Buyer: - Ce...

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