Artificial Intelligence Procurement Opportunities at Department of Health and Human Services

The Department of Health and Human Services (HHS) is actively procuring AI-related IT services primarily through the Centers for Disease Control and Prevention (CDC) and the Health Resources and Services Administration (HRSA). Recent solicitations emphasize maintenance, modernization, and support of data-centric applications related to HIV prevention and cloud enterprise systems.

Market Analysis

• The CDC Division of HIV Prevention issued a multi-year maintenance and administration RFP for its HIV Data Coordinating Center (GSA Alliant 2 #RFP1817605), with a response deadline of June 29, 2026.
• Another CDC solicitation (GSA #RFQ1817639) targets IT services for the Secure HIV-TRACE bioinformatics application, with proposals due by July 7, 2026.
• HRSA released a solicitation for comprehensive software development and operations support for cloud and enterprise applications (GSA #RFQ1815906), closing June 16, 2026.
• The CDC's nationwide Customer Information Technology Support Services (CITS) solicitation (GSA Alliant 2 #RFP1810356) closed June 17, 2026, indicating ongoing demand for broad IT support.
• Most solicitations fall under NAICS codes 541511 (Custom Computer Programming Services) and 541519 (Other Computer Related Services), reflecting a focus on software development and IT consulting.

Frequently Asked Questions

How can I find current HHS AI-related solicitations?

Use keywords like "HHS AI RFP" or "Health and Human Services AI solicitation" on federal procurement platforms such as SAM.gov. Filter results by buyer agency (Department of Health and Human Services) and NAICS codes 541511 or 541519 to narrow to relevant IT and AI service contracts.

What are the typical response deadlines for these HHS AI solicitations?

Recent solicitations have response deadlines clustered in June and early July 2026. For example, the CDC HIV Data Coordinating Center RFP closes June 29, 2026, and the Secure HIV-TRACE application RFQ closes July 7, 2026. Monitor deadlines closely as they can vary by solicitation.

Are there set-aside requirements for small businesses in these opportunities?

The provided solicitations do not explicitly state set-asides, but many HHS IT contracts under NAICS 541511 and 541519 include small business set-asides or subcontracting opportunities. Review each solicitation's specific acquisition strategy and FAR clauses for set-aside status.

Which contract vehicles are commonly used for HHS AI procurements?

GSA Alliant 2 is a frequent vehicle, as seen in multiple CDC solicitations (e.g., #RFP1817605, #RFP1810356). Additionally, standalone RFQs and RFPs are posted directly by HHS components. Familiarity with GSA Alliant 2 and direct agency solicitations is essential.

Who are the incumbent contractors for these HHS AI-related IT services?

Incumbent information is not explicitly provided in the current solicitations. However, contractors with experience supporting CDC HIV data systems or HRSA cloud applications are likely incumbents or strong competitors. Checking past awards on FPDS.gov can provide more insight.