The Department of Health and Human Services (HHS) is currently advancing several AI procurement initiatives, notably the FDA's enterprise workflow management modernization and CDC's global informatics support. These solicitations emphasize AI integration and cloud computing services, with multiple deadlines clustered in April 2026.
Use the GSA eBuy and SAM.gov portals to search for active solicitations with keywords like "HHS AI RFP" or "Health and Human Services AI solicitation." Filter by NAICS codes 541511 (Custom Computer Programming Services) and 541519 (Other Computer Related Services) to narrow results.
Recent solicitations have clustered deadlines in early to mid-April 2026, with some RFIs and RFQs requiring responses within 1-2 weeks of posting. Monitor postings closely to meet tight turnaround times.
Most current HHS AI solicitations do not specify small business set-asides but verify each solicitation individually. Some may be unrestricted or open to all qualified contractors.
GSA Alliant 2 and GSA MAS are frequently used vehicles, as seen with CDC and FDA solicitations. Familiarity with these vehicles can facilitate proposal submissions.
Incumbent information is not always publicly disclosed in initial solicitations. However, contractors with prior experience supporting CDC, FDA, or HRSA informatics and AI projects may have an advantage.
CDC Global Health Center Informatics and IT Support Services Solicitation
The Centers for Disease Control and Prevention (CDC), through its Global Health Center and Office of Acquisition Services, is seeking proposals for comprehensive Informatics and IT Support services...
Support and Enhancement Services for openFDA Platform
This opportunity seeks contractor support for the openFDA platform, which provides public FDA data in machine-readable formats for AI and analytics applications. - Government Buyer: - Department ...
FDA Enterprise Workflow Management Systems BPA – Development, Modernization, and AI Integration
The U.S. Food and Drug Administration (FDA), part of the Department of Health and Human Services, is seeking contractor support for the full lifecycle of enterprise-scale workflow management system...
AI/ML Fraud Detection and Management Platform Development for HRSA
The Health Resources and Services Administration (HRSA) Office of Budget and Finance is seeking advanced AI/ML services to develop and support a Fraud Detection and Management Platform (FDMP) for g...
CDC Solicitation for AWS Cloud Capacity and Compute Services (GSA MAS SIN 518210C)
This opportunity from the Centers for Disease Control and Prevention (CDC) seeks AWS cloud computing services for federal operations, with a focus on prepaid consumption credits and consolidated bi...
HRSA BPA for IT Operations, Maintenance, and Data Engineering Services for Data and Web Platforms
The Health Resources and Services Administration (HRSA), part of the U.S. Department of Health and Human Services, is seeking small business sources for a Blanket Purchase Agreement (BPA) to provid...
Procurement of Marketplace System Integrator (MSI) Services for CMS Health Insurance Exchange
This procurement opportunity is for the Centers for Medicare & Medicaid Services (CMS), specifically the Center for Consumer Information and Insurance Oversight (CCIIO) under the Marketplace In...
HRSA's BPA for Software and Cloud Support Systems
The Health Resources and Services Administration (HRSA), operating under the Department of Health and Human Services (HHS), is soliciting contracted services for software development, operational s...
HRSA Software Development and Support Services for Custom Applications and SharePoint Collaboration Solutions
This procurement opportunity is issued by the Department of Health and Human Services (HHS), specifically the Health Resources and Services Administration (HRSA), for comprehensive software develop...
CDC Request for Quote for Data Modernization Initiative Cloud Platform and Related Technical Support Services
This opportunity involves the Centers for Disease Control and Prevention (CDC) seeking technical support services to advance its Data Modernization Initiative (DMI) through cloud technology. - Gove...
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