Artificial Intelligence Procurement Opportunities at Department of Health and Human Services

The Department of Health and Human Services (HHS) is currently issuing several solicitations targeting AI-enabled IT services to support health data systems modernization and maintenance. Notable contracts include CDC's Secure HIV-TRACE application and CMS's FHIR server operation, both critical for advancing public health informatics.

Market Analysis

Frequently Asked Questions

How can I find current HHS AI-related solicitations?

Use keywords like "HHS AI RFP" or "Health and Human Services AI solicitation" on federal procurement platforms such as SAM.gov or GSA eBuy. Focus on solicitations posted by CDC and CMS under NAICS codes 541511 and 541519.

What are the key deadlines for upcoming HHS AI procurements?

Several active opportunities have response deadlines in July 2026, notably July 8 for the ICD-10-CM modernization RFI (RFI1819636), July 13 for CMS FHIR server support (RFQ1820443) and CDC cancer surveillance modernization (RFP1819864), and July 15 for the Secure HIV-TRACE application (RFQ1817639).

Are there set-aside requirements or small business considerations?

While the current solicitations do not explicitly state set-asides, many HHS IT contracts under these NAICS codes often include small business or 8(a) set-asides. Review each solicitation's specific acquisition strategy for details.

Which contract vehicles are commonly used for HHS AI procurements?

GSA STARS3 and Alliant 2 GWACs are frequently used for these procurements, providing streamlined access for contractors with relevant IT and AI capabilities.

Who are the incumbent contractors for these HHS AI-related contracts?

Incumbent information is typically disclosed in the solicitation documents or past award notices. For example, the CDC's HIV Data Coordinating Center contract (RFP1817605) may have incumbent vendors specializing in bioinformatics and health data management services.

Recent Opportunities

GSA #RFQ1820013

CDC Solicits Support Services for National Cancer Registries and Surveillance Systems

Department of Health and Human Services Posted June 26, 2026 Respond by July 24, 2026

The Centers for Disease Control and Prevention (CDC), through its Office of Financial Resources and Office of Acquisition Services, is seeking a contractor to provide comprehensive support services...

GSA #RFP1823266

NIH NLM Software Development, Automation, and Cloud Support Services

Department of Health and Human Services Posted July 14, 2026 Respond by July 29, 2026

The National Institutes of Health (NIH), National Library of Medicine (NLM), Office of Computer and Communications Systems (OCCS) is seeking a contractor for comprehensive software development, aut...

GSA STARS3 #RFP1821407

CMS AI-Enabled Provider Compliance Self-Assessment Tool and Support Services

Department of Health and Human Services Posted July 09, 2026 Respond by July 20, 2026

This opportunity is a multi-year procurement by the Centers for Medicare & Medicaid Services (CMS) to develop and support an AI-enabled provider compliance self-assessment tool for post-acute c...

GSA #RFQ1823324

CDC NeuVector Software License Renewal (72 Licenses, 12-Month Term)

Department of Health and Human Services Posted July 14, 2026 Respond by July 22, 2026

The Centers for Disease Control and Prevention (CDC) is seeking quotes for the renewal of NeuVector software licenses to secure its containerized and Kubernetes-based workloads across multi-cloud e...

GSA #RFQ1817639

CDC Seeks IT Services for Secure HIV-TRACE Application Operations, Modernization, and Support

Department of Health and Human Services Posted June 12, 2026 Respond by July 15, 2026

The Centers for Disease Control and Prevention (CDC), Division of HIV Prevention, is seeking IT professional services for the Secure HIV-TRACE bioinformatics application. - Government Buyer: - Ce...

GSA #RFQ1821675

CDC Solicits Agile IT Services for NEDSS Base System Modernization and Support

Department of Health and Human Services Posted July 13, 2026 Respond by August 03, 2026

The Centers for Disease Control and Prevention (CDC), through its Office of Public Health Data, Surveillance, and Technology (OPHDST), Investigate and Respond Division (IRD), is seeking Agile IT se...

GSA #RFQ1820443

CMS Solicitation for PCG FHIR Server Operation, Maintenance, and Enhancement Services

Department of Health and Human Services Posted June 29, 2026 Respond by July 15, 2026

The Centers for Medicare & Medicaid Services (CMS), Division of Medicare & Medicaid Information Technology Support Contracts, is seeking IT professional services to support the Provider Com...

GSA STARS3 #RFP1819864

CDC Seeks Contractor for Cancer Surveillance Informatics System Support and Modernization

Department of Health and Human Services Posted June 25, 2026 Respond by July 13, 2026

This opportunity is issued by the Centers for Disease Control and Prevention (CDC), National Center for Chronic Disease Prevention and Health Promotion, Division of Cancer Prevention and Control, C...

GSA #RFI1819636

RFI: Modernization of ICD-10-CM Classification Management System

Department of Health and Human Services Posted June 24, 2026 Respond by July 08, 2026

The Department of Health and Human Services, through the Centers for Disease Control and Prevention (CDC) and its National Center for Health Statistics (NCHS), is seeking information on modernizing...

GSA Alliant 2 #RFP1817605

CDC Seeks Multi-Year Maintenance and Administration Services for HIV Data Coordinating Center

Department of Health and Human Services Posted June 12, 2026 Respond by June 29, 2026

The Centers for Disease Control and Prevention (CDC), Division of HIV Prevention, is seeking a contractor to provide comprehensive maintenance and administration services for its Data Coordinating ...

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