Simpler Grants.gov #RFA-RM-27-016

NIH SenNet funding opportunity for cellular senescence research centers

The NIH Common Fund is inviting applications for SenNet Discovery and Validation Centers focused on cellular senescence research. - Government buyer: National Institutes of Health (NIH), NIH Common Fund, Cellular Senescence Network (SenNet). - Opportunity type: Research funding through a cooperative agreement, not a procurement of commercial products or services. - Proposed work: Define, refine, and validate tissue- and disease-relevant cellular senescence signatures (senotypes) and biomarkers; investigate their effects in human health and disease; and contribute high-quality molecular, cellular, and spatial datasets with metadata and documentation. - Key requirements: Applications should describe approaches for validating findings and characterizing responses to senescence-associated perturbations or senotherapeutic approaches. They should also propose consortium-wide organizational and outreach activities. - Expected awards: NIH expects to make 25 awards. - OEMs, vendors, products, and quantities: None identified in the provided information.

Description

This Notice of Funding Opportunity supports SenNet Discovery and Validation Centers as a core component of Stage 2 of the NIH Common Fund Cellular Senescence Network. The centers will define, refine, and validate tissue- and disease-relevant cellular senescence signatures (senotypes) and associated biomarkers, and investigate their functional consequences in human health and disease. They are expected to generate and contribute high-quality molecular, cellular, and spatial datasets with relevant metadata and documentation, and use complementary experimental systems as appropriate to validate findings and characterize responses to senescence-associated perturbations or senotherapeutic approaches. Applications should also propose goals and aims for SenNet consortium-wide organizational and outreach activities.

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