# Simpler Grants.gov #RFA-RM-27-016

NIH SenNet funding opportunity for cellular senescence research centers

**Buyer:** National Institutes of Health
**Posted:** October 09, 2026
**Respond By:** November 23, 2026
**Identifier:** RFA-RM-27-016
**NAICS:** 541714, 541715

The NIH Common Fund is inviting applications for SenNet Discovery and Validation Centers focused on cellular senescence research.
- **Government buyer:** National Institutes of Health (NIH), NIH Common Fund, Cellular Senescence Network (SenNet).
- **Opportunity type:** Research funding through a cooperative agreement, not a procurement of commercial products or services.
- **Proposed work:** Define, refine, and validate tissue- and disease-relevant cellular senescence signatures (senotypes) and biomarkers; investigate their effects in human health and disease; and contribute high-quality molecular, cellular, and spatial datasets with metadata and documentation.
- **Key requirements:** Applications should describe approaches for validating findings and characterizing responses to senescence-associated perturbations or senotherapeutic approaches. They should also propose consortium-wide organizational and outreach activities.
- **Expected awards:** NIH expects to make 25 awards.
- **OEMs, vendors, products, and quantities:** None identified in the provided information.

### Description

This Notice of Funding Opportunity supports SenNet Discovery and Validation Centers as a core component of Stage 2 of the NIH Common Fund Cellular Senescence Network. The centers will define, refine, and validate tissue- and disease-relevant cellular senescence signatures (senotypes) and associated biomarkers, and investigate their functional consequences in human health and disease. They are expected to generate and contribute high-quality molecular, cellular, and spatial datasets with relevant metadata and documentation, and use complementary experimental systems as appropriate to validate findings and characterize responses to senescence-associated perturbations or senotherapeutic approaches. Applications should also propose goals and aims for SenNet consortium-wide organizational and outreach activities.

[View original listing](https://simpler.grants.gov/opportunity/359169)