Opportunity
SAM #DHSSBIRFY27PRE
DHS FY27.1 SBIR research and development opportunity across three homeland security topics
Buyer
Science and Technology Acquisition Division
Posted
November 13, 2026
Respond By
December 07, 2026
Identifier
DHSSBIRFY27PRE
NAICS
541714, 541720, 541715
DHS is planning a FY27.1 Small Business Innovation Research (SBIR) competition for small-business research and development across three homeland security topics. - Government buyer: U.S. Department of Homeland Security (DHS), DHS SBIR Program, Office of Procurement Operations, Science and Technology Acquisition Division. - OEMs and vendors: No manufacturers, OEMs, or vendors are named; no commercial products are specified. - Research topics: - DHS271-001: Human Digital Twins Verification System. - DHS271-002: Bacterial Pathogen Origin Determination via Direct Methylome Sequencing. - DHS271-003: Direct Detection and Differentiation of Prion Protein Isoforms. - Anticipated research awards: - Phase I: $175,000–$265,000 for 5–8 months. - Phase II: $1,000,000–$1,500,000 for 24–36 months, including any requested Technical and Business Assistance. - Phase II work builds on Phase I and is expected to deliver topic-specific prototypes and validation outcomes. Phase II submissions depend on the applicable instructions and notice to Phase I awardees. - Eligibility considerations: The program is for small businesses. Firms majority-owned by multiple venture capital operating companies, hedge funds, or private equity firms are ineligible; Phase I offerors must meet or exceed the SBA Phase II Transition Rate Benchmark. - This is a pre-solicitation notice; proposals are not currently being requested.
Description
THIS IS A PRE-SOLICITATION - DHS IS NOT SEEKING PROPOSALS AT THIS TIME
The Department of Homeland Security (DHS) Small Business Innovation Research (SBIR) Program invites small business concerns (SBCs) to review this Pre-Solicitation for awareness of the upcoming 27.1 DHS SBIR Solicitation.
Please read the attached Pre-Solicitation carefully. This Pre-Solicitation is being provided for planning purposes, to allow SBCs to become familiar with the requirements for the upcoming 27.1 Solicitation. Failure to comply with the requirements in the 27.1 Solicitation will likely result negatively in the proposal evaluation or elimination from consideration for award. The final 27.1 Solicitation may differ from the Pre-Solicitation. This Pre-Solicitation contains topics for the DHS SBIR Program. Unsolicited proposals will not be accepted. Prior to proposal submission, Offerors must register with SAM.gov and the Small Business Administration (SBA) Company Registration Database. Note – Completion of SAM.gov registration can be a lengthy process (up to several weeks). It is recommended to initiate this as soon as possible. Offerors that are majority‐owned by multiple venture capital operating companies, hedge funds or private equity firms are NOT ELIGIBLE to submit proposals in response to the 27.1 Solicitation. Per the SBA SBIR Policy Directive, dated May 3, 2023, to be eligible for a Phase I award, Offerors must meet or exceed the Phase II Transition Rate Benchmark.
SEE ATTACHED PRE-SOLICITATION FOR FULL DETAILS