Simpler Grants.gov #RFA-RM-27-009

Renewal funding for the Gabriella Miller Kids First Pediatric Data Resource Center

NIH is renewing support for the Gabriella Miller Kids First Pediatric Data Resource Center, a cloud-based resource for pediatric genomic research. - Government buyer: Department of Health and Human Services; National Institutes of Health (NIH) Common Fund, through the Office of Strategic Coordination; administered by the National Cancer Institute (NCI). - Applicant: Children's Hospital of Philadelphia is identified as the sole eligible applicant—the existing recipient. - Requested services: Continue developing and operating the Data Resource Core, Data Coordination Core, and Administrative Core. Work includes maintaining and expanding the portal, repository, analysis workspaces, and tools; coordinating data submission, quality control, registration, harmonization, and release; and supporting program administration, training, outreach, and research-community resources. - Research focus: Enable access, analysis, and sharing of annotated genomic and related phenotypic data to advance research on childhood cancers and congenital anomalies. - Notable requirements: Coordinate with NCI's Cancer Research Data Commons and deliver developed resource software as open-source. Clinical trials are not allowed. - Funding and term: One three-year cooperative agreement is anticipated, with up to $5 million available per year. Annual application budgets are capped at $3.2 million in direct costs, plus applicable indirect costs. - OEMs and commercial vendors: No product manufacturers or commercial vendors are specified.

Description

This Notice of Funding Opportunity invites applications for the continued development of the Gabriella Miller Kids First Pediatric Data Resource Center, comprising a Data Resource Core, Data Coordination Core, and Administrative Core. The cloud-based resource supports discovery of genetic causes and shared biological pathways in childhood cancers and congenital anomalies by enabling access to and querying of annotated genomic and phenotypic data. Work includes aggregating, analyzing, and sharing data; coordinating data collection and harmonization with Kids First investigators and genomic data generation centers; and providing administration, training, outreach, and community resources. The NIH Common Fund intends to fund one three-year cooperative agreement, contingent on available funds, with up to $5 million per year and annual application budgets limited to $3.2 million in direct costs plus applicable indirect costs.

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