Michigan VSS #ITN-491-270000000003-1

Michigan newborn screening: second-tier dried-blood-spot testing and interpretation

Michigan’s newborn screening program is seeking specialized second-tier dried-blood-spot testing and interpretation for several serious inherited disorders. - Government buyer: Michigan Department of Health and Human Services (MDHHS), Bureau of Laboratories (MDHHS-BOL), Lansing, Michigan. - Named provider: Mayo Medical Laboratories (MML) is identified as the intended provider and as the only provider able to meet the specified testing and interpretation requirements. - Services requested: Perform second-tier tests on dried blood spots and interpret the results. No testing quantities are stated. - Congenital adrenal hyperplasia: 17-hydroxyprogesterone, androstenedione, cortisol, 11-deoxycortisol, and 21-deoxycortisol. - Propionic acidemia, methylmalonic acidemia, and homocystinuria: total homocysteine, methylmalonic acid, and methylcitric acid. - Mucopolysaccharidosis types I–IV: heparan sulfate and dermatan sulfate. - Pompe disease: creatine, creatinine, and acid-alpha glucosidase activity. - Maple Syrup Urine Disease: alloisoleucine, leucine, isoleucine, and valine. - Glutaric acidemia: hydroxyglutaric acids, glutaric acid, ethylmalonic acid, and methylsuccinic acid. - X-linked adrenoleukodystrophy: lysophosphatidylcholines measured by liquid chromatography-tandem mass spectrometry. - Period of performance: Not specified.

Description

The Michigan Department of Health and Human Services Bureau of Laboratories intends to contract with Mayo Medical Laboratories for second-tier testing of dried blood spots and interpretation of results for newborn screening. Testing covers analytes for congenital adrenal hyperplasia, PA/MMA/HCU, mucopolysaccharidosis types I–IV, Pompe disease, Maple Syrup Urine Disease, glutaric acidemia, and X-linked adrenoleukodystrophy. The source states that Mayo Medical Laboratories is the only service provider conducting these tests on dried blood spots with the methodology and interpretation needed by the MDHHS laboratory.

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