SAM #NSF-Topic4-FY26-XLabsSequence-to-Function

NSF X-Labs bioengineering R&D team awards

The U.S. National Science Foundation is seeking bioengineering teams to develop transformative platform technologies through its NSF X-Labs initiative. - Government buyer: U.S. National Science Foundation (NSF), Directorate for Technology, Innovation and Partnerships (TIP). - OEMs and vendors: No product manufacturers, OEMs, or commercial vendors are identified. - Requested work: Full-time R&D teams developing novel platform technologies with the potential to create high-impact scientific or technological breakthroughs, including in bioengineering. - Award phases: - Phase 0: 9–12 months, up to $1.5 million, for concept development, milestone refinement, and preparation for a full team. - Phase 1: 24–36 months, up to $50 million per year, to execute the team’s mission, scale operations, and recruit full-time team members. - Phase 2 renewal may be available based on performance; advancement between phases is milestone-based. - Key requirements: Teams should demonstrate operational autonomy and independence. Senior and key personnel are expected to be dedicated full-time by Phase 1.

Description

The National Science Foundation (NSF) Directorate for Technology, Innovation and Partnerships (TIP) announces its intent to solicit Written Proposals for NSF X-Labs teams in the technical domain of bioengineering. This NSF X-Labs announcement is issued under the Other Transactions Agreement Solutions Offering (OTASO), NSF-OTASO-FY26-XLabsInitiative.

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