NHLBI-AI #NHLBI-SI-25-002

NHLBI Precision Medicine Coordinating Center services for HLBS research

NHLBI is seeking one or more coordinating centers to support its precision medicine research across heart, lung, blood, and sleep health. - Government buyer: National Institutes of Health (NIH), through the National Heart, Lung, and Blood Institute (NHLBI); no specific office is identified. - Named organizations: Westat/AICC is identified in connection with the solicitation; NHLBI’s BioData Catalyst (BDC) is the research data ecosystem with which awardees must collaborate. TOPMed and NHLBI cohort data are cited as relevant data sources. - OEMs: None are identified. No commercial products, part numbers, or product quantities are requested. - Services requested: Precision Medicine Coordinating Center (PMCC) activities, including scientific leadership, program management, subject-matter expertise, and coordination and oversight of modular research programs and individual projects. Centers will support collaborative research using existing and newly collected human-subjects data and work with BDC on data management, harmonization, and sharing in secure computing environments. - Notable requirements: Applicants must propose a measurable, milestone-based workplan and provide monthly progress and outcome reporting. Requirements include human-subjects protections and compliance with NIH cybersecurity, privacy, data-sharing, genomic-data, public-access, and research-resource policies. Non-commercial software must be open source or provided with unlimited Government rights; hardware designs must provide at least Government Purpose Rights. - Term: The anticipated award period is up to four years; specific start and end dates are not stated.

Description

The opportunity seeks Letters of Request from applicants interested in establishing one or more Precision Medicine Coordinating Centers (PMCCs) for the NHLBI-SI Enabled Precision Medicine Initiative for Heart, Lung, Blood, and Sleep (HLBS) Health. PMCCs will support modular research programs and individual SI projects using deep phenotyping and systems biology to understand HLBS health, deconstruct conditions, and identify potential treatment targets. The work includes program management and subject matter expertise for collaborative HLBS research involving existing and newly generated human-subjects data, in coordination with NHLBI’s BioData Catalyst ecosystem. Applicants first submit a Letter of Request, with selected teams invited to submit a full application; the stated award term is up to four years.

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