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NHLBI-SI Initiative seeks innovative research projects in Heart, Lung, Blood, and Sleep health

The National Heart, Lung, and Blood Institute (NHLBI) is seeking individual research projects through its NHLBI-SI Initiative to advance Heart, Lung, Blood, and Sleep health and disease research. - Government buyer: National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI), through the NHLBI-SI Initiative. - Research sought: Projects applying scientific innovation to HLBS research, including developing foundation models; analyzing multi-omics, clinical, exposome, or imaging data; identifying disease-related molecular phenotypes; and building predictive models for precision medicine and community health. - Data resources: Use of TOPMed data and the BioData Catalyst ecosystem is encouraged. - Project scale: Proposed study periods may be one, two, or three years. Total project costs may not exceed $5 million, including direct and indirect costs. - Key requirements: Include milestone-based workplans and address data management and sharing, privacy, and security. Open-source or unlimited rights for non-commercial software, models, documentation, and technical data are preferred. - Application process and status: Applicants begin with a Letter of Request; only invited applicants may submit a full application. The notice is closed to new applicants. - OEMs and vendors: No commercial OEMs, product vendors, or specific products are identified.

Description

This funding opportunity solicits individual research projects applying scientific innovation (SI) to improve understanding, prevention, diagnosis, and treatment of Heart, Lung, Blood, and Sleep (HLBS) health and disease. Areas of interest include foundation models, multi-omics and clinical data analysis, and predictive models for precision medicine and community health; use of TOPMed data and the BioData Catalyst ecosystem is encouraged. The application process begins with a Letter of Request, and only applicants with compelling LORs may be invited to submit a full application. The maximum total project cost is $5 million, including direct and indirect costs, for a study period of up to three years; the notice states it is closed to new applicants.

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