Simpler Grants.gov #RFA-RM-27-007

NIH SenNet opportunity for development and validation of cellular senescence technologies

The National Institutes of Health is seeking research teams to develop and validate technologies for studying cellular senescence through its SenNet program. - Buyer: National Institutes of Health (NIH), Common Fund Cellular Senescence Program; SenNet Technology Projects (SenTecs), solicitation RFA-RM-27-007. - Purpose: Develop new technologies or adapt existing ones to identify and characterize senescent-cell diversity, study its effects in tissue environments and secretomes, support in-vivo strategies for modulating senescent cells, and predict effects of targeting these cells in human aging and disease. - Required project structure: A two-year UG3 phase for technology development and feasibility, followed by a three-year UH3 phase for application, optimization, refinement, and validation. The final year includes a collaborative demonstration project within SenNet. - Important requirements: Proposals must address both phases; clinical trials are not allowed. - Funding: NIH anticipates 15 awards and $6 million in total program funding. - OEMs, vendors, products, and quantities: None are specified; this is a research and technology-development opportunity rather than a purchase of named products.

Description

This opportunity seeks the development of innovative senescence technologies or adaptation of existing technologies to identify and characterize senescent cell heterogeneity and understand its biological consequences. The technologies are intended to support strategies for modulating senescent cells in vivo and predicting outcomes of targeting them in human aging and disease. Awards are five years and milestone-driven: two years for technology development and feasibility (UG3), followed by three years for application, optimization, refinement, and validation (UH3). Applicants must submit both phases together; transition to UH3 is subject to administrative review, and the final year includes a collaborative SenNet demonstration project.

View original listing