Simpler Grants.gov #RFA-HG-27-009

NIH/NHGRI research awards on genetic and environmental interactions affecting genomic variant impact

The National Institutes of Health is seeking research applications to investigate how genetic and environmental interactions influence the effects of genomic variants. - Government buyer: National Institutes of Health (NIH), through the National Human Genome Research Institute (NHGRI). - Research requested: Establish interaction centers to develop research frameworks and experimentally test combinations of genomic variants and other factors that may alter variant impact. - Data sharing and collaboration: Share data, analyses, methods, and prediction approaches through the Impact of Genomic Variation on Function (IGVF) portal and catalog; coordinate with other IGVF Consortium components on assays, variants, cell types, and analysis strategies. - Funding: Estimated total program funding is $10,000,000, with five awards expected and a maximum of $1,500,000 per award. - Notable requirements: Clinical trials are not allowed. Foreign organizations and foreign components may participate, but applications involving foreign subawards or subcontracts are ineligible for funding. - OEMs, vendors, and purchased items: No OEMs, vendors, products, part numbers, quantities, or purchased services are identified.

Description

This Notice of Funding Opportunity seeks applications to study how genetic or environmental interactions affect the impact of genomic variants. Interaction centers will develop research frameworks and experimentally test variant combinations, then share data, analyses, and prediction methods through the IGVF portal and catalog. Centers will collaborate with other IGVF Consortium components to coordinate assays, variants, cell types, and analysis strategies. The opportunity has estimated program funding of $10,000,000, expects five awards, and lists a maximum award of $1,500,000.

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