Simpler Grants.gov #PAR-27-045

NIH HEAL Initiative Clinical Research Funding for Joint Pain Mechanisms

The National Institutes of Health (NIH) is announcing a Notice of Funding Opportunity (NOFO) under the HEAL Initiative for clinical research on joint pain mechanisms. - Government Buyer: - National Institutes of Health (NIH) - HEAL Initiative management - OEMs and Vendors: - No specific OEMs or vendors are named; the opportunity is for clinical research services - Products/Services Requested: - Phased mechanistic clinical research program - Focus on identifying and validating multi-tissue biological mechanisms driving joint pain - Testing non-pharmacologic or multimodal interventions targeting these mechanisms - No specific products, part numbers, or quantities requested - Unique/Notable Requirements: - Projects must align with priorities from the 2023 HEAL Whole Joint Pain Workshop - Eligible applicants include U.S.-based government entities, educational institutions, nonprofits, and businesses - Foreign organizations and non-U.S. components are excluded - Maximum project duration is five years - Emphasis on safe, non-addictive, and prevention-oriented approaches to chronic pain

Description

The NIH Helping to End Addiction Long-term® (HEAL) Initiative is releasing this Notice of Funding Opportunity (NOFO) to support a phased mechanistic clinical research program focusing on understudied biological mechanisms that drive joint pain. The program supports projects up to five years in duration that will identify and validate multi-tissue mechanisms underlying joint pain and test non-pharmacologic or multimodal interventions targeting these mechanisms. This initiative aligns with the 2023 HEAL Whole Joint Pain Workshop priorities and aims to advance safe, non-addictive, and prevention-oriented approaches to chronic pain.

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