SAM #75N98026Q01209

NIH seeks DNA methylation profiling and epigenetic age analysis for murine samples

NIH's National Institute on Aging is seeking specialized DNA methylation profiling and epigenetic age analysis for murine DNA samples. - Government Buyer: - National Institutes of Health (NIH) - National Institute on Aging (NIA) - Office of the Director, Office of Acquisitions - OEM/Vendor: - Epigenetic Clock Development Foundation (sole source) - Products/Services Requested: - DNA methylation profiling and epigenetic age analysis for 320 murine DNA samples - Includes 80 blood-derived and 240 tissue-derived samples from various organs - Utilizes Mammal320K methylation array and Horvath epigenetic clock methodologies - Services include bisulfite conversion, array processing, scanning, quality control, bioinformatic analyses, and delivery of raw data, biological age estimates, and summary analyses - Unique Requirements: - Analysis compares Normoxic Control, Intermittent Hypoxia, and Intermittent Hyperoxia conditions - Deliverables include quality control documentation, biological age estimates, and bioinformatic comparison across experimental groups - Non-competitive procurement due to specialized expertise and proprietary methods - No specific part numbers or additional OEMs referenced - Estimated period of performance is approximately 6 weeks after sample receipt

Description

(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested, and a separate written solicitation will not be issued.(ii) The solicitation number is 75N98026Q01209/PCA-NIA-08501. This solicitation is issued as a Notice of Intent (NOI) for a non-competitive combined synopsis/solicitation to award a contract or purchase order without providing for full and open competition (including brand-name, if applicable).This acquisition is conducted under the authority of FAR 12.603, Streamlined Solicitation for Commercial Products or Commercial Services, and is not expected to exceed the simplified acquisition threshold. Additional authority includes 41 U.S.C. 1901 and FAR 6.302-3(a)(2)(ii).The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, intends to negotiate and award a firm fix-price award on a non-competitive basis to Epigenetic Clock Development Foundation 1124 W. Carson Street, MRL Bldg., 3rd Floor Torrance, CA 90502 US to provide obtain DNA methylation profiling and epigenetic age analysis for 320 previously extracted murine DNA samples using the Mammal320K methylation array and established Horvath epigenetic clock methodologies.

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