SAM #75N98026R00085

NIH sole-source contract to University of Illinois at Chicago for preclinical animal research on sAC inhibition in pulmonary arterial hypertension

This opportunity is a sole-source contract from the National Institutes of Health (NIH) to the University of Illinois at Chicago (UIC) for specialized preclinical animal research services. - Agency: National Institutes of Health (NIH), Office of Acquisitions and Logistics Management - Vendor: University of Illinois at Chicago (UIC) - Purpose: Evaluate the therapeutic effects of soluble adenylyl cyclase (sAC) inhibition in pulmonary arterial hypertension (PAH) - Uses a unique EC-Cav1 knockout (KO) mouse model maintained only at UIC - Scope of work: - Breeding and maintenance of 144 mice (EC-Cav1 KO and wild-type controls) - Genotyping, drug administration (KH7 and LRE1 inhibitors), and vehicle control - Maintenance of hypoxia chambers - Echocardiography, right-heart catheterization, euthanasia, necropsy - Tissue collection for histology, Western blotting, RNA-seq, serum/plasma collection - Government will supply 200 mg each of KH7 and LRE1 sAC inhibitors - Sole-source justification: UIC is the only known source for the required mouse colony - No specific commercial products or part numbers are being procured; focus is on research services - Period of performance: 12 months from award, expected on or before September 30, 2026 - Estimated contract value: $100,000 - $250,000 - No competing vendors identified due to unique research requirements

Description

The National Institutes of Health (NIH) intends to negotiate on a sole-source basis with the University of Illinois at Chicago (UIC) for preclinical animal research services to evaluate the therapeutic effects of soluble adenylyl cyclase (sAC) inhibition on pulmonary arterial hypertension (PAH) using an established endothelial cell-specific Cav1 knockout (EC-Cav1 KO) murine model and corresponding wild-type controls.

The Government intends to solicit from a single source pursuant to FAR 13.106-1(b)(1). UIC currently maintains the established EC-Cav1 KO mouse colony required for this study, and the model is not known to be maintained by another laboratory.

This notice of intent is not a request for competitive quotations. However, all responsible sources that believe they can satisfy the Government's requirements may submit a capability statement and/or quotation for consideration by the Government.

Please see the attached Notice of Intent to Sole Source for the complete description of the requirement, basis for the intended sole-source acquisition, response instructions, and applicable response deadline.

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