SAM #75N98026Q01193ENAMINEUSINCPCANIAAA08396

Laboratory Testing and Assay Development Services for ADME and PK Studies

This opportunity from the National Institutes of Health (NIH), Office of Logistics and Acquisition Operations (OLAO), seeks specialized laboratory testing and assay development services. - Government Buyer: - National Institutes of Health (NIH), Office of Logistics and Acquisition Operations (OLAO), Department of Health and Human Services - OEMs and Vendors: - ENAMINE US INC (named vendor) - Products/Services Requested: - Laboratory testing and assay development services - Grouped ADME (Absorption, Distribution, Metabolism, and Excretion) assays - Pharmacokinetic (PK) study in C57BL6 mice - Caco-2 Permeability Assay (to predict oral absorption potential) - Unique/Notable Requirements: - Inclusion of Caco-2 Permeability Assay for structure-activity relationship optimization - No specific products or part numbers; focus is on specialized laboratory services - ENAMINE US INC is the only vendor named; no competing vendors or products are specified.

Description

The Section on Medicinal Chemistry (SMC) develops new molecular entities with implications in improving health and treatment for various metabolic and alcohol associated diseases. To assess the translational potential of novel molecular entities, which would allow us to make decisions to proceed the compounds for further development we utilize multiple derisking assays. These assays comprise of both cell-based (in vitro) testing and then eventually in mice to assess pharmacokinetic parameters to see if the drug is orally available. 

Request to procure Chemical Reagent (Assay) Development & Laboratory Testing Service SMC to produce grouped ADME assays and perform a Pharmacokinetic study in C57BL6 mice. By including the Caco-2 Permeability Assay in our ADME evaluation it'll accurately predict the oral absorption potential of our compounds. This well-established in vitro model closely mimics the human intestinal epithelium, providing critical insights into a compound’s passive diffusion, active transport, and efflux processes, such as those mediated by P-glycoprotein (P-gp). The data generated from this assay are vital for informing structure-activity relationship (SAR) optimization, improving compound permeability, and reducing transporter-related liabilities that could hinder bioavailability

View original listing