SAM #75N98026Q01192

NIH Procurement of 10x Genomics Single-Cell Gene Expression Kits and Reagents

This opportunity from the National Institutes of Health (NIH), National Institute on Aging (NIA), and Center for Alzheimer's and Related Dementias (CARD) supports advanced neurodegenerative disease research. - Government Buyer: - National Institutes of Health (NIH) - National Institute on Aging (NIA) - Center for Alzheimer's and Related Dementias (CARD) - OEM Highlight: - 10x Genomics is the sole OEM referenced for all requested products - Products Requested: - GEM-X Epi Multiome (16 samples, part number 1000979, qty: 1) - GEM-X Universal 3' Gene Expression v4 (48 samples, part number 1000711, qty: 6) - Dual Index Kit TT Set A (96 reactions, part number 1000215, qty: 4) - Dual Index Kit TS Set A (96 reactions, part number 1000251, qty: 1) - Chromium GEM-X Single Cell 3' Chip Kit v4 (4 chips, part number 1000690, qty: 11) - GEM-X Flex v2 Human (384 samples, part number 1000929, qty: 1) - GEM-X Flex Gel Bead & Library Kit v2 (4 reactions, part number 1000919, qty: 4) - GEM-X Flex Gene Expression Chip Kit (4 chips, part number 1000791, qty: 1) - Notable Requirements: - All kits and reagents must be compatible with 10x Genomics Chromium X and iX instruments - Products support high-throughput single-cell epigenomic profiling for spatial molecular analysis - Quantities and part numbers are specified for each item - No services are requested; all items are products - No other OEMs or vendors are mentioned

Description

The National Institute on Aging (NIA) and the Center for Alzheimer's and Related Dementias (CARD) requires Single Cell Multiome kits to understand the molecular mechanisms underlying neurodegenerative disease with Lewy body pathology. CARD will use these reagents to study the molecular differences and similarities between Parkinson’s Disease, Dementia with Lewy bodies and neurologically normal individuals. This spatial analysis will allow us to see which parts of the brain are affected and examine how things are dysregulated in different diseases. This may contribute to identifying therapeutic genes and pathways that can be targeted to improve symptoms and disease states.   Please see the attached product description for a complete list of items required and the sailenent charecteristics required for each.

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