SAM #75N98026Q01158

NIH Sole-Source Contract for 5-Base Whole Genome Sequencing Services (IDENTIFY Study)

This opportunity is a sole-source procurement by NIH's National Human Genome Research Institute (NHGRI) for advanced genomic sequencing services supporting the IDENTIFY study. - Agency: National Institutes of Health (NIH), NHGRI, Center for Precision Health Research, Prenatal Genomics and Therapy Section - Sole-source contract to The Broad Institute, Inc. - Services required: - 5-base sample preparation and whole genome multiomic profiling - Sequencing of plasma-derived cell-free DNA samples from women with prenatal results suggestive of maternal malignancy - Generation of high-resolution genomic and epigenomic data at 30x coverage - Data and technical documentation delivery to support tissue-of-origin analysis and computational model development - Emphasis on scientific continuity with previous data for research validity - Period of performance: 12 months, anticipated start date 09/25/2026 - No specific product part numbers or quantities provided; focus is on service delivery - Commercial competitors may include other advanced genomics service providers, but Broad Institute is specified as sole source - Estimated contract value likely in the mid-to-high six figures, based on scope and industry standards

Description

The Prenatal Genomics and Therapy Section (PGTS), Center for Precision Health Research (CPHR), National Human Genome Research Institute (NHGRI), requires 5-base whole genome sequencing services for stored plasma-derived cell-free DNA samples collected under the IDENTIFY study. These samples were obtained from women who received prenatal cell-free DNA sequencing results suggestive of maternal malignancy. 5Base sample prep and whole genome multiomic profiling at 30x is required to generate high-resolution genomic and epigenomic data suitable for tissue-of-origin analyses. 

The objective of this acquisition is to obtain high-quality, comprehensive 5-base sequencing data that will support the development and refinement of computational models to determine the tissue source of incidentally detected maternal cancers. The resulting data will be incorporated into ongoing bioinformatic and translational research efforts within PGTS to improve interpretation of prenatal cell-free DNA sequencing results, enhance early cancer detection strategies in pregnancy, and advance understanding of circulating cell-free DNA biology in the context of malignancy. 

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