SAM #75N98026Q01145

NIH Solicitation for Laboratory Equipment Supporting Stem Cell Gene Therapy Research

The National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI), is procuring specialized laboratory equipment to advance research in hematopoietic stem cell-targeted lipid nanoparticle gene delivery for in vivo gene therapy. - Government Buyer: - NIH, National Heart, Lung, and Blood Institute (NHLBI), Office of the Director, Office of Acquisitions - Requested Products: - Ignite+ Upgrade Kit (1 unit) - Enables higher-throughput lipid nanoparticle formulation - Increases maximum working volume from 20 mL to 60 mL and flow rate from 20 mL/min to 200 mL/min - Must be compatible with existing Ignite device - AKTA flux S Semi-Automated Tangential Flow Filtration (TFF) System (1 unit) - Used for larger-scale purification of lipid nanoparticles - Supports 0.22 µm sterile filtration - Requires benchtop installation with clearance for tubing and filter cartridge - VIA Freeze Duo Controlled Rate Freezer (1 unit) - Liquid-nitrogen-free, conduction-cooling freezer for cryopreservation of human CD34+ stem cells and lipid nanoparticles - Supports high-efficiency recovery and remote monitoring via Ethernet - OEMs and Vendors: - No specific OEMs or brands are named, but requested items are commonly manufactured by companies such as Sartorius (Ignite+), Cytiva (AKTA flux S), and Cytiva or Asymptote (VIA Freeze Duo) - Unique Requirements: - Equipment must meet detailed technical specifications and be compatible with existing NIH devices - Delivery required as soon as possible after award, with offerors to specify delivery timeline - Equipment must support high-throughput, scalable, and efficient processing for gene therapy research - Delivery Location: - Bethesda, MD - Opportunity is unrestricted under NAICS 334516 (Analytical Laboratory Instrument Manufacturing)

Description

(i) This is a combined synopsis/solicitation for commercial items prepared in accordancewith FAR Subpart 12.6, as supplemented with additional information included in thisnotice. This announcement constitutes the only solicitation; proposals are beingrequested, and a separate written solicitation will not be issued.(ii) The solicitation number is 75N98026Q01145. This solicitation is issued as a competitivecombined synopsis/solicitation for commercial products or commercial services. TheGovernment intends to award a contract or purchase order resulting from this solicitationusing full and open competition.This acquisition is conducted under the authority of FAR 12.603, Streamlined Solicitationfor Commercial Products or Commercial Services, and is not expected to exceed thesimplified acquisition threshold.The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, seeksto award a firm-fixed-price purchase order to the responsible offeror whose proposalrepresents the best value to the Government.(iii) The solicitation document and incorporated provisions and clauses are those in effectthrough Federal Acquisition Circular 2026-01, effective 03/13/2026.(iv) The associated NAICS code is 334516 ¿ Analytical Laboratory InstrumentManufacturing, and the small business size standard is 1,000 employees.¿ This requirement is unrestricted.(v) Description of Requirement:The National Heart, Lung, and Blood Institute (NHLBI) requires the following commerciallyavailable laboratory equipment to support research on hematopoietic stem cell (HSC)-targeted lipid nanoparticle (LNP) gene delivery for the advancement of in vivo gene therapy.Offerors shall provide equipment meeting or exceeding the salient characteristics below.

View original listing