Simpler Grants.gov #RFA-NS-27-002

NIH BRAIN Initiative: Integrative Team-Research BRAIN Circuits Program Funding Opportunity

This opportunity is issued by the National Institutes of Health (NIH), specifically the National Institute of Neurological Disorders and Stroke (NINDS), to support the BRAIN Initiative: Integrative Team-Research BRAIN Circuits Program (iBCP). - Government Buyer: - National Institutes of Health (NIH) - National Institute of Neurological Disorders and Stroke (NINDS) - Purpose: - Funding for transdisciplinary research teams to develop mechanistic, biologically grounded explanations of how neural circuits and their cellular building blocks contribute to central nervous system (CNS) function - Key Requirements: - Teams must integrate expertise across molecular, cellular, and systems neuroscience - Strong collaboration between experimental and computational investigators is required - Projects must explicitly connect: - Characterization of circuit components (e.g., cell types, connectivity) - Measurement of dynamic circuit activity (including in vivo CNS recordings at cellular and sub-second temporal resolution) - Analysis of a tractable behavior or functional output - Use of innovative frameworks, predictive models, and cutting-edge approaches is encouraged - Participation in BRAIN consortia activities to establish standards for multi-level integration - Restrictions on foreign organizations and subawards - Eligibility includes government, nonprofit, business, and educational entities - OEMs and Vendors: - No specific OEMs or vendors are named, as this is a research grant opportunity, not a procurement of products or services - Products/Services Requested: - Support for research teams (no specific products or part numbers requested) - Notable Requirements: - Emphasis on multi-disciplinary collaboration and integration - Participation in broader BRAIN Initiative consortia - Restrictions on foreign participation and subawards

Description

This Notice of Funding Opportunity supports transdisciplinary research teams aiming to develop mechanistic, biologically grounded explanations of how neural circuits and their cellular components contribute to central nervous system function. Teams must integrate expertise from molecular and cellular to systems neuroscience, combining experimental and computational approaches to link cells, circuits, and behavior. Applications must explicitly address characterization of circuit components, measurement of dynamic circuit activity with in vivo CNS recordings, and analysis of behavior or functional output. Proposed studies should leverage innovative frameworks and predictive models to unify these analyses and participate in BRAIN consortia activities to establish standards for multi-level integration.

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