SAM #DARPA-PA-25-07-06

DARPA SHINE Program Solicitation for Circuit-Selective Neuroplasticity Research and Prototype Development

DARPA's Defense Sciences Office (DSO) is seeking innovative research proposals for the SHINE program, targeting circuit-selective neuroplasticity. - Government Buyer: - Defense Advanced Research Projects Agency (DARPA), Defense Sciences Office (DSO) - OEMs and Vendors: - DARPA (soliciting agency; no commercial OEMs or vendors specified) - Products/Services Requested: - Research and development services for targeted neuroplasticity - Track A: Clinical-ready prototype development - Design, assembly, and integration of systems combining therapeutics, biologics, devices, physical modalities, behavioral interventions, or combination approaches - Must use existing human safety data or established regulatory pathways - Demonstration and validation in clinical populations or translationally relevant animal models - Track B: Foundational technology development - High-risk, high-payoff design and laboratory-scale synthesis of novel prototype platforms - Includes biologics, engineered cellular systems, biomaterials, synthetic biology, precision neuromodulation, behavioral paradigms, or other enabling technologies - Evaluation in vitro or in preclinical animal models - Unique/Notable Requirements: - Focus on selective induction of adaptive neuroplasticity with quantitative metrics - Emphasis on non-invasive or minimally invasive approaches - Excludes systemic drug discovery and invasive implants - Awards are made as Other Transaction (OT) for Prototype Agreements - Maximum award value per agreement is $2,000,000 (including cost share) - Program duration is 18 months with fixed milestones - Two tracks: clinical translation and foundational technology - Demonstration of pathway to animal trials or clinical validation required

Description

The Defense Advanced Research Projects Agency (DARPA) Defense Sciences Office (DSO) is issuing a Disruption Opportunity (DO), inviting submissions of innovative basic or applied research concepts in the technical domain of targeted neuroplasticity. This DO is issued under the Program Announcement for Disruptioneering, DARPA-PA-25-07 Amendment 1. All awards will be made in the form of an Other Transaction (OT) for Prototype Agreement. The total award value for this DO is limited to $2,000,000 per award. This total award value includes Government funding and performer cost share if required or proposed.Additional Links:Original Solication: DARPA-PA-25-07 - Disruptioneering Program Announcement

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