SAM #PANAPG-26-P-0000-051608

Sole Source Custom Aptamer Procurement for U.S. Army DEVCOM CBC

This notice announces the U.S. Army's intent to award a sole source contract for custom aptamer production. - Agency: U.S. Army Contracting Command – Aberdeen Proving Ground (ACC-APG), Edgewood Division - End user: U.S. Army Combat Capabilities Development Command Chemical Biological Center (DEVCOM CBC) - Sole source vendor: Aptagen, LLC (CAGE Code 436H7) - Products: Custom DNA, RNA, and peptide aptamers (with or without chemical modifications), delivered lyophilized - Aptamers must be purified using denaturing Polyacrylamide Gel Electrophoresis (dPAGE) - Standard HPLC or cartridge purification methods are not acceptable - Services: Double-tier empirical sequence verification required for each delivery order - Verification by ElectroSpray Ionization (ESI) Mass Spectrometry and 10% Urea Gel dPAGE analysis - Purpose: Aptamers to be used as biological recognition elements in diagnostic assay development, biosensor research, and chemical/biological defense platforms - Commercial opportunity: Sole source procurement; Aptagen, LLC identified as only capable vendor - No competing vendors or products identified due to unique requirements - Contract type: Firm Fixed Price - No specific quantities or period of performance provided

Description

The U.S. Army Contracting Command – Aberdeen Proving Ground (ACC-APG), Edgewood Division intends to issue a Firm Fixed Price award on a sole source basis in accordance with Revolutionary Federal Acquisition Regulation Overhaul (RFO) FAR 6.103-1 to support the U.S. Army Combat Capabilities Development Command Chemical Biological Center (DEVCOM CBC) and their requirement for a mission-critical, continuing requirement for the custom synthesis, purification, quality control, and delivery of deoxyribonucleic acid (DNA), ribonucleic acid (RNA), and peptide aptamers, with or without chemical modifications  delivered in lyophilized form. These aptamers serve as foundational biological recognition elements in diagnostic assay development, biosensor research, and chemical/biological defense mission-support platforms.

The synthesized aptamers will undergo denaturing Polyacrylamide Gel Electrophoresis (dPAGE) purification. Standard commercial HPLC or cartridge purification is technically unacceptable.

The vendor will provide empirical sequence-verification data using both ElectroSpray Ionization (ESI) Mass Spectrometry and 10% Urea Gel dPAGE analysis with every delivery order (Double-Tier Empirical Quality Control).

The intent is to award this contract to Aptagen, LLC., CAGE Code 436H7.  Aptagen LLC. is located at 250 North Main Street, Jacobus, PA 17407.  At this time, it is the Government’s understanding that no other contractor is capable of supplying the required aptamers.

This notice of intent is not a request for competitive quotations; however, all responses received within seven (7) days of the issuance of this notice will be reviewed accordingly by the Government. Any response should be emailed to Contract Specialist, Sammy Solo at sammy.b.solo.civ@army.mil and Contracting Officer, Nicholas Granata Jr. at nicholas.granata.civ@army.mil by 3:00 pm EST on 26 August 2026.

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