SAM #36C24126Q0748

Sole Source RRBS Sequencing Services for VA Bedford Healthcare System

This opportunity is a sole source procurement by the VA Bedford Healthcare System for specialized epigenome sequencing services. - Agency: Department of Veterans Affairs, VA Bedford Healthcare System, Network Contracting Office 1 (NCO-1) - Sole source contract to Zymo Research Corporation - Service: Reduced Representation Bisulfite Sequencing (RRBS) for DNA methylation profiling - 269 post-mortem human choroid plexus tissue samples - Includes sample handling, quality control, bisulfite conversion, library preparation, sequencing (~30 million read pairs per sample), and bioinformatics analysis - Requirement: Must use same laboratory, personnel, and protocol as prior dataset for scientific comparability - Justification: Only Zymo Research can meet the technical need to avoid laboratory-origin confounds - NAICS code: 541714 (Research and Development in Biotechnology) - No competing vendors or products referenced - Commercial opportunity is limited due to sole source justification

Period of Performance: - Not specified in the notice or attachments

OEMs: - Zymo Research Corporation

Potential Competitors: - No competitors listed due to sole source justification, but similar companies could include Illumina, Thermo Fisher Scientific, and Qiagen

Primary Products/Services: - Reduced Representation Bisulfite Sequencing (RRBS) services

Estimated Contract Value: - Likely in the range of $100,000 to $300,000 based on sample volume and sequencing complexity

Product/Service Line Items: - RRBS services for 269 samples, including all steps from sample handling to sequencing and data analysis

Description

Notice of intent to award a sole source contract. This is not a solicitation. The Department of Veterans Affairs intends to negotiate a sole source contract with: ZYMO RESEARCH CORPORATION 17062 Murphy Avenue Irvine, California 92614, United States MNUYHHMKG8N9

This is not a solicitation. The Department of Veterans Affairs, VA Bedford Healthcare System intends to award a sole source, firm-fixed-price contract to Zymo Research Corporation for Reduced Representation Bisulfite Sequencing (RRBS) services for DNA methylation profiling of 269 post-mortem human choroid plexus tissue samples. Description of Supplies/Services: RRBS services on 269 post-mortem human choroid plexus tissue samples, including sample handling and QC assessment, bisulfite conversion, library preparation and QC assessment, sequencing (~30 million read pairs per sample), and raw data alignment, methylation calling, and genome browser track generation. This requirement supports an ongoing VA research study requiring DNA methylation data from choroid plexus tissue that is directly comparable, at the laboratory-batch level, to an existing dorsolateral prefrontal cortex methylation dataset previously generated in its entirety by Zymo Research Corporation for the same study. Introducing a second laboratory to generate the choroid plexus data would create a vendor-of-origin technical confound that is inseparable from the biological comparison the study is designed to detect, and this confound cannot be reliably resolved through statistical correction after the fact. Zymo Research Corporation is the only vendor that can generate this data using the same laboratory, personnel, and protocol as the existing dataset, thereby preserving the scientific validity of the planned cross-tissue comparison. The contractor will provide the required services. Since the intent is to procure this on a sole source basis, no solicitation will be posted to Contracting Opportunities SAM.gov. A Sources Sought Notice (36C241-26-AP-4037) was previously posted for this requirement; responses received did not identify a source able to meet this specific requirement without introducing the technical confound described above. The authority for this action is RFO 6.103-1, Only One Responsible Source and No Other Supplies or Services Will Satisfy the Agency's Requirements. The NAICS code is 541714. The size standard is 1,000 employees. The PSC is Q301. Interested persons may contact the Contract Specialist by email at [email] regarding this procurement. The determination to conduct a competitive procurement based on responses to this notice is solely within the discretion of the Contracting Officer. Response must be received by 8/21/26 NLT 11:00am EST.

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