SAM #75N98026Q00943

NIH Chromium X Controller Upgrade Procurement

The National Institutes of Health (NIH), through the Office of Logistics and Operations (OLAO) and the Hospital and Laboratory Support Division, is seeking to upgrade its single-cell analysis capabilities. - Government Buyer: - National Institutes of Health (NIH) - Office of Logistics and Operations (OLAO) - Hospital and Laboratory Support Division - OEM Highlight: - 10X Genomics, Inc. (manufacturer of the Chromium X Controller) - Products/Services Requested: - Chromium X Controller upgrade - Utilizes Next GEM technology for multi-dimensional single-cell analysis - Compatible with existing 5’ v2 kits - Research Applications: - Transcriptomic profiling of cerebrospinal fluid, blood immune cells, and autopsy brain tissue - Supports studies of neurodegenerative disorders (multiple sclerosis, HAM/TSP, PML) - Notable Requirements: - Upgrade must be compatible with previously acquired kits - Device is used for advanced single-cell analysis (transcriptome, cell surface proteins, immune clonotypes, antigen specificity, chromatin accessibility) - NAICS code: 334516 - No specific part numbers or quantities provided in the notice.

Description

General Information

Document Type:

Presolicitation

Synopsis Number:

75N98026Q00943

Posted Date:

August 14, 2026

Original Response Date:

August 24, 2026

Current Response Date:

August 24, 2026

Set Aside:

N/A

NAICS Code:

334516

Contracting Office Address

National Institutes of Health (NIH), Office of the Director (OD)

Office of Logistics and Operations (OLAO)

Office of Acquisition and Logistics Management (OALM)

Hospital and Laboratory Support Division

6701 Rockledge Drive

Bethesda, MD 20817 

Description

INTRODUCTION

THIS IS A PRE-SOLICITATION NON-COMPETITIVE (NOTICE OF INTENT) SYNOPSIS TO AWARD A CONTRACT OR PURCHASE ORDER WITHOUT PROVIDING FOR FULL OR OPEN COMPETITION (INCLUDING BRAND-NAME).

The National Institutes of Health (NIH) intends to negotiate and award a contract without providing for full and open competition (Including brand-name) to:

10X Genomics, Inc.

6230, Stoneridge Mall Road

Pleasanton, California

94588

NORTH AMERICAN INDUSTRY CLASSIFICATION SYSTEM (NAICS) CODE

The intended procurement is classified under NAICS code 334516 with a Size Standard N/A.

REGULATORY AUTHORITY

The resultant contract will include all applicable provisions and clauses in effect through the Federal Acquisition Circular (FAC) 2026-01, March 13, 2026. This acquisition is conducted under the procedures as prescribed in FAR subpart 13-Simplified Acquisition Procedures at an amount not exceeding the simplified acquisition threshold ($350,000).

STATUTORY AUTHORITY

This acquisition is conducted under the authority of the Federal Acquisition Regulation (FAR) Part 13-Simplified Acquisition Procedures, Subpart 13.106-1 (b) (1), Soliciting from a single source and is not expected to exceed the simplified acquisition threshold. Contracts awarded using FAR Part 13-Simplified Acquisition Procedures are exempt from the requirements of FAR Part 6-Competition Requirements.

GENERAL INFORMATION

Title: Chromium X controller upgrade Background Information: The Chromium X Controller has been a key tool in our collaborative research group for single-cell research. Utilizing Next GEM technology, it enables multi-dimensional single-cell analysis on a single system. This machine provides molecular readouts of cell activity across various dimensions, including gene expression, cell surface proteins, immune clonotypes, antigen specificity, and chromatin accessibility. Our lab has been using the previous model with 5’ v2 kits, which remain compatible with the newest version, allowing us to continue using previously acquired kits.

We use the 10X controller (and relevant reagents) for measuring the transcriptome of freshly obtained cells of the cerebrospinal fluid (CSF) and blood immune cells (peripheral blood mononuclear cells – PBMCs) from participants enrolled in clinical studies/trials to uncover biology. In addition, we have used the system for single-nuclei from autopsy tissue (mostly the brain). In future projects, we intend on using the 10X genomics system for the membranes covering the brain and in using the device for transcriptomic profiling of PFA- and FFPE-fixed tissues – this is because we want to use the vast amount of tissue collected as part of various studies in our branch to help answer biological questions pertinent to these neurodegenerative brain disorders. All these tissues are relevant to both normal physiology and in the context of diseases.

The output is multi-dimensional, measuring not only the transcriptome (the entire messenger RNA ensemble of each cell), but including and not limited to cell surface proteins on the cells and the receptors of certain immune cells. This enables us to study multiple cell types and their interactions which is important to dissect the underlying mechanisms behind these disorders. The output includes scRNAseq, scTCR/BCR-seq (sequencing the transcriptome and receptors on T- and B-cells) and CITEseq (measuring cell surface proteins on each cell). Our group is intending on using this device for multiple sclerosis (MS), HAM/TSP (Tropical spastic paraparesis) and PML (Progressive multifocal leukoencephalopathy) primarily.

CLOSING STATEMENT

This synopsis is not a request for competitive proposals. However, interested parties may identify their interest and capability to respond to this notice. Responses to this notice shall contain sufficient information to establish the interested parties' bona-fide capabilities for fulfilling the requirement and include a technical proposal, a cost-price proposal, the period of performance, the Unique Entity ID (UEI), the Taxpayer Identification Number (TIN), and the certification of business size. All offerors must have an active registration in the System for Award Management (SAM) www.sam.gov.

A determination by the Government not to compete this proposed contract based upon responses to this notice is solely within the discretion of the Government. The information received will normally be considered solely for the purposes of determining whether to proceed on a non-competitive basis or to conduct a competitive procurement.

All responses must be received by August 24, 2026 at 9:00 AM Eastern time and must reference solicitation number 75N98026Q00943. Responses may be submitted electronically to Mr. James Law, Contracting Officer at James.Law@nih.gov. Fax responses will not be accepted.

"All responsible sources may submit a capability statement, proposal, or quotation, which shall be considered by the agency.”

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