SAM #75N98026Q00993

NIH Solicitation for Mouse PK/PD Study Services for NNMT Inhibitors

The National Institutes of Health (NIH), Office of the Director, Office of Logistics and Acquisition Operations, is seeking proposals for mouse PK/PD (pharmacokinetic/pharmacodynamic) study services focused on NNMT (Nicotinamide N-methyltransferase) inhibitors. - Government Buyer: - National Institutes of Health (NIH), Office of the Director, Office of Logistics and Acquisition Operations - Products/Services Requested: - Mouse PK/PD study services for NNMT inhibitors - Includes animal handling, dosing, biological sample collection, bioanalytical testing, pharmacokinetic analysis, data management, and reporting - Study covers 10 test articles supplied by NCATS (8 monitored for parent compound only, 2 monitored for parent and 1-methylnicotinamide) - Deliverables: plasma concentration data, concentration-versus-time tables and curves, calculated PK parameters, and final study report - OEMs and Vendors: - No specific OEMs or vendors are named; requirement is for commercially available nonclinical study services - Unique or Notable Requirements: - Vendor must be able to handle all aspects of mouse PK/PD studies for NNMT inhibitors - Must provide comprehensive data and reporting as specified - All test articles are supplied by NCATS - Services must be completed within a three-month period, with the final report due within three weeks after study completion

Description

(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes only solicitation; proposals are being requested, and a separate written solicitation will not be issued.(ii) The solicitation number is 75N98026Q00993. This solicitation is issued as a competitive combined synopsis/solicitation for commercial products or commercial services. The Government intends to award a contract or purchase order resulting from this solicitation using full and open competition.This acquisition is conducted under the authority of FAR 12.603, Streamlined Solicitation for Commercial Products or Commercial Services, and is not expected to exceed the simplified acquisition threshold (if applicable).The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, seeks to award a (Firm-Fixed-Price) to the offeror responsible whose proposal represents the best value to the Government.(iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular effective August 7, 2026(iv) The associated NAICS code is 541715 Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) and the small business size standard is 1000 employees.This requirement is unrestricted.

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