SAM #75N98026Q00989

NIH Solicitation: Non-GLP Maximum Tolerated Dose (MTD) Study of PIP4Kgamma Lead Compound NCGC00592266 in Mice

The National Institutes of Health (NIH), Office of the Director, Office of Logistics and Multiple Acquisition Operations, is seeking a contractor to conduct a preclinical Maximum Tolerated Dose (MTD) study for the PIP4Kgamma lead compound NCGC00592266. - Government Buyer: - National Institutes of Health (NIH), Office of the Director, Office of Logistics and Multiple Acquisition Operations - OEMs and Vendors: - No specific OEMs or commercial vendors are named; the compound NCGC00592266 is referenced as the subject of the study - Products/Services Requested: - Non-GLP MTD study of PIP4Kgamma lead compound NCGC00592266 in CD1 SPF mice - 30 mice (5 dose groups, 3 male and 3 female per group) - Intraperitoneal administration - Includes animal acclimation, veterinary supervision, dose formulation, clinical and cage-side observations, post-dose monitoring, body weight monitoring, necropsy, tissue preservation, and preparation of a standard non-GLP study report - Service includes provision of qualified personnel (PhD-level Study Director, Scientist, technical/animal care staff) - Unique/Notable Requirements: - Study must be non-GLP (Good Laboratory Practice not required) - Deliverables include detailed clinical observations, body weight data, mortality/toxicity findings, necropsy results, and a comprehensive study report - Supports preclinical development of the compound NCGC00592266 - NAICS code: 541715 (Research and Development in the Physical, Engineering, and Life Sciences, except Nanotechnology and Biotechnology) - Firm-fixed-price contract; best value selection

Description

(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes only solicitation; proposals are being requested, and a separate written solicitation will not be issued.(ii) The solicitation number is 75N98026Q00989. This solicitation is issued as a competitive combined synopsis/solicitation for commercial products or commercial services. The Government intends to award a contract or purchase order resulting from this solicitation using full and open competition.This acquisition is conducted under the authority of FAR 12.603, Streamlined Solicitation for Commercial Products or Commercial Services, and is not expected to exceed the simplified acquisition threshold (if applicable).The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, seeks to award a (Firm-Fixed-Price) to the offeror responsible whose proposal represents the best value to the Government.(iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular effective August 7, 2026(iv) The associated NAICS code is 541715 Research and Development in the Physical, Engineering, and Life Sciences (except Nanotechnology and Biotechnology) and the small business size standard is 1000 employees.This requirement is unrestricted.

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