SAM #75N98026Q00986

Pharmacokinetic and Pharmacodynamic Studies of NNMT Inhibitors for Chronic Kidney Disease

The National Institutes of Health (NIH), Office of the Director, Office of Logistics and Multiple Acquisition Operations, is seeking a contractor to conduct pharmacokinetic (PK) and pharmacodynamic (PD) studies for selective small-molecule NNMT inhibitors targeting chronic kidney disease. - Government Buyer: - National Institutes of Health (NIH) - Office of the Director - Office of Logistics and Multiple Acquisition Operations - Products/Services Requested: - PK/PD studies of three selective small-molecule NNMT inhibitors - IV and oral single-dose studies in mice - Monitoring plasma concentrations over 24 hours - Deliverables: blood work and PK results reports (including concentration vs time curves and PK parameters in Excel) - Unique/Notable Requirements: - Contractor must ensure confidentiality; all data and results are owned by the government - Studies must include both parent compound and 1-MNA monitoring - OEMs and Vendors: - No specific OEMs or vendors are named; the opportunity is open to qualified research service providers - Quantities: - One comprehensive PK/PD study covering three NNMT inhibitors

Description

(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes only solicitation; proposals are being requested, and a separate written solicitation will not be issued.(ii) The solicitation number is 75N98026Q00986. This solicitation is issued as a competitive combined synopsis/solicitation for commercial products or commercial services. The Government intends to award a contract or purchase order resulting from this solicitation using full and open competition.This acquisition is conducted under the authority of FAR 12.603, Streamlined Solicitation for Commercial Products or Commercial Services, and is not expected to exceed the simplified acquisition threshold (if applicable).The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, seeks to award a (Firm-Fixed-Price) to the offeror responsible whose proposal represents the best value to the Government.(iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular effective August 7, 2026(iv) The associated NAICS code is 325414 Biological Product (except Diagnostic) Manufacturing and the small business size standard is 1250 Employees.This requirement is unrestricted.

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