SAM #75N98026Q00976

NIH Solicitation for Pharmacokinetic Studies of RXFP1-Agonists in Mice

The National Institutes of Health (NIH), Office of the Director, Office of Logistics and Multiple Acquisition Operations, is seeking commercial laboratory services for pharmacokinetic (PK) studies of RXFP1-agonist compounds. - Government Buyer: - National Institutes of Health (NIH) - Office of the Director - Office of Logistics and Multiple Acquisition Operations - OEMs and Vendors: - No specific OEMs or vendors are named; opportunity is open to qualified commercial testing laboratories - Products/Services Requested: - Pharmacokinetic (PK) studies for four RXFP1-agonist compounds - Study design includes: - Intraperitoneal administration (10 mg/kg) in male C57BL/6J mice - Single-dose PK study - 3 animals per time point - 8 sampling time points - Collection of plasma, lung, liver, and heart tissues - Quantitative bioanalysis and calculation of PK parameters - Delivery of raw concentration data, electronic data files, and final study report - Unique/Notable Requirements: - Studies must support medicinal chemistry and publication efforts - Rapid turnaround time: estimated 5 working days for in vivo studies - Firm-fixed-price contract - All data and reports must be delivered electronically

Description

(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes only solicitation; proposals are being requested, and a separate written solicitation will not be issued.(ii) The solicitation number is 75N98026Q00976. This solicitation is issued as a competitive combined synopsis/solicitation for commercial products or commercial services. The Government intends to award a contract or purchase order resulting from this solicitation using full and open competition.This acquisition is conducted under the authority of FAR 12.603, Streamlined Solicitation for Commercial Products or Commercial Services, and is not expected to exceed the simplified acquisition threshold (if applicable).The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, seeks to award a (Firm-Fixed-Price) to the offeror responsible whose proposal represents the best value to the Government.(iii) The solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular effective August 7, 2026(iv) The associated NAICS code is 541380 Testing Laboratories and Services, and the small business size standard is $19.0 million.This requirement is unrestricted.

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