SAM #75F40126Q135715

FDA Solicitation for RNA Sequencing and Bioinformatic Analysis of Rat Brain Tissue Samples

The U.S. Food and Drug Administration (FDA) National Center for Toxicological Research (NCTR), Division of Neurotoxicology, is soliciting specialized laboratory and data analysis services for a neuroscience research project. - Government Buyer: - U.S. Food and Drug Administration (FDA) - National Center for Toxicological Research (NCTR) - Division of Neurotoxicology (DNT) - Scope of Work: - Total tissue sample RNA isolation, mRNA library preparation, sequencing, and bioinformatic processing/analysis - Analysis of 256 rat brain tissue samples - Differential expression analysis across four brain regions, multiple treatment groups, and both sexes - Deliverables include detailed reports and all supporting data files - Products/Services Requested: - RNA isolation and mRNA library preparation using PolyA enrichment or a comparable strategy - Sequencing at 15-30 million paired-end 50-150 bp reads per sample - Bioinformatic analysis: quality control, genome alignment, differential expression, and functional enrichment analysis - Notable Requirements: - All results and data must be delivered within 6 months of sample receipt - Firm-fixed price contract; pricing must remain firm through the government’s sample delivery deadline - No specific OEMs or commercial vendors are named in the solicitation - The opportunity is open to all qualified vendors with relevant laboratory and bioinformatics capabilities

Description

See Attached Combined Synopsis/Solicitation 75F40126Q135715

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