NHLBI-AI #NHLBI-AI-25-002

NHLBI Solicits Precision Medicine Coordinating Center for AI-Enabled HLBS Research

The National Heart, Lung, and Blood Institute (NHLBI) is seeking to establish a Precision Medicine Coordinating Center (PMCC) to support its AI-Enabled Precision Medicine Initiative for Heart, Lung, Blood, and Sleep (HLBS) health. - Government Buyer: - National Heart, Lung, and Blood Institute (NHLBI) - Artificial Intelligence Coordinating Center (AICC) - OEMs and Vendors: - No specific OEMs or commercial vendors are named - Key referenced platforms: BioData Catalyst (BDC), Trans-Omics for Precision Medicine (TOPMed) - Products/Services Requested: - Establishment and operation of a PMCC to provide: - Program management and scientific coordination for HLBS AI research - Support for modular research programs and individual AI projects - Data harmonization, protocol development, and participant consent guidance - Collaboration with NHLBI BioData Catalyst and Data Science Center - Oversight of ethical, legal, and social implications (ELSI) - Creation and management of new research cohorts - Unique or Notable Requirements: - Use and integration of high-value, machine-readable HLBS datasets (e.g., TOPMed, BDC) - Compliance with NIH data sharing, open-source software, and cybersecurity policies - Protections for human subjects and genomic data - Eligible applicants include higher education institutions, nonprofits, for-profits, FFRDCs, and UARCs - Projected funding of $56M over 5 years, with a PMCC award term up to 4 years

Description

The NHLBI-AI Initiative seeks to establish at least one Precision Medicine Coordinating Center (PMCC) to accelerate AI research related to heart, lung, blood, and sleep (HLBS) health. The PMCC will support modular research programs, provide program management, and collaborate with the NHLBI BioData Catalyst ecosystem. The center will focus on deep phenotyping, systems biology approaches, and managing human subjects data for collaborative research. Applicants must submit a Letter of Request by September 30, 2025, with a subsequent full application if invited. Eligible applicants include higher education institutions, nonprofits, for-profits, FFRDCs, and UARCs.

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