NHLBI-AI #NHLBI-AI-25-003

NHLBI PREEMPT-PF Scientific Coordinating Center for Pulmonary Fibrosis Research

This opportunity is issued by the National Heart, Lung, and Blood Institute (NHLBI), part of the National Institutes of Health, seeking a Scientific Coordinating Center (SCC) for the PREEMPT-PF program focused on pulmonary fibrosis research. - Government Buyer: - National Heart, Lung, and Blood Institute (NHLBI) - Artificial Intelligence Coordinating Center (AICC) - NHLBI Artificial Intelligence Coordinating Center (Westat) - Scope of Work: - Establish and manage the Scientific Coordinating Center (SCC) for the PREEMPT-PF program - Lead program infrastructure and governance, including forming a Scientific Leadership Committee - Oversee human subject recruitment, data collection, and quality management - Support and coordinate mechanistic pilot projects and future clinical research projects - Integrate artificial intelligence tools and systems biology approaches - Collaborate with other NHLBI-AI components and NIH programs (e.g., TOPMed, BioData Catalyst, BioLINCC, LungMAP, HuBMAP) - Ensure open science, data sharing, and open-source software standards - Comply with NIH data and cybersecurity policies - Provide milestone-based reporting and support workforce development - Funding and Performance: - Initial commitment of $20 million over three years, with potential for additional funding - Funding mechanism is Other Transactions Authority (OTA) subaward - Milestone-based workplan with annual budget review - Eligibility: - Open to higher education institutions, nonprofits, for-profit organizations, FFRDCs, UARCs, and non-domestic entities - Notable Requirements: - Emphasis on open science, data sharing, and compliance with NIH policies - Integration of AI and systems biology for early evaluation and mechanistic preemption of pulmonary fibrosis

Description

This funding opportunity solicits applications for the Scientific Coordinating Center (SCC) of the PREEMPT-PF program, which aims to understand and preemptively treat pulmonary fibrosis by leveraging deep phenotyping and systems biology. The SCC will establish infrastructure, form a Scientific Leadership Committee, manage human subject recruitment and data quality, support workforce development, and oversee mechanistic pilot projects and future clinical research projects. The program is funded by NHLBI with an initial commitment of $20 million over 3 years, with potential additional funding in future years. The application process involves submitting a Letter of Request by December 17, 2025, followed by a full application due March 12, 2026.

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