NIH Reporter #1K23NS140388-01A1

Research Grant Award for Neurophysiological Study of Cognition in Epilepsy Patients

This opportunity involves a research grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) to Massachusetts General Hospital for a study on cognition in epilepsy patients. - Government Buyer: - National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS) - Awardee: - Massachusetts General Hospital - OEMs and Vendors: - No specific OEMs or commercial vendors are mentioned - Products/Services Requested: - Research services focused on neurophysiological correlates of cognition in temporal lobe epilepsy - Use of home-based digital cognitive assessments - Neurophysiology data collection, including continuous EEG and Responsive Neurostimulator (RNS) device recordings - Unique/Notable Requirements: - Integration of digital cognitive assessments in both hospital and home settings - Collection and analysis of multi-day neurophysiology data - Focus on quantifying hippocampal interictal epileptiform activity - Estimated/Awarded Value: - $234,630 - No specific products, part numbers, or purchase quantities are listed

Description

This project aims to advance understanding of the neurophysiological basis of cognitive impairment over multi-day timescales in epilepsy patients. It involves leveraging home-based digital cognitive assessments and neurophysiology data collection in patients with temporal lobe epilepsy. The study includes patients undergoing continuous EEG recordings and those implanted with Responsive Neurostimulator devices to quantify hippocampal interictal epileptiform activity. The goal is to inform future strategies to better prevent and treat cognitive dysfunction in epilepsy.

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