NIH Reporter #5F31AI186227-02

Immunotherapy Research Grant Awarded to Johns Hopkins University for T Cell Metabolic Target Identification

This opportunity involves a research grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) to Johns Hopkins University for immunotherapy research. - Government Buyer: - National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S. National Institutes of Health - Awardee/Vendor: - Johns Hopkins University - Products/Services Requested: - Research and development project focused on identifying metabolic targets to reinvigorate exhausted CD8+ T cells - Utilizes metabolomics, CRISPR screening, and systems biology approaches - Lump sum quantity: 1 research project - Unique/Notable Requirements: - Experience in immunotherapy research - Use of advanced metabolomics and genetic screening techniques - No specific OEMs are mentioned; the focus is on scientific research and development - Potential competitors include organizations with expertise in immunotherapy and advanced biological research

Description

This project aims to identify metabolic targets to reinvigorate exhausted CD8+ T cells, which are critical for immune defense but become dysfunctional after prolonged antigen exposure. The research involves using metabolomics, CRISPR screening, and systems biology approaches to understand the metabolic pathways influencing T cell exhaustion. Conducted at Johns Hopkins University, the study seeks to restore T cell function to improve immunotherapy outcomes. The project duration is from May 1, 2025, to April 30, 2027, with an award amount of $50,114.

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