NIH Reporter #5R01DK138907-02

NIDDK Research Grant: Role of Fibroblasts in Bladder Mucosal Function

This opportunity is a research grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health, focused on bladder mucosal function. - Government Buyer: - National Institutes of Health (NIH) - National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) - Recipient: University of Pittsburgh at Pittsburgh - Purpose: - Research on the role of suburothelial fibroblasts (SUFs) in bladder mucosal function - Investigate molecular mechanisms by which SUFs contribute to the viscoelastic properties of the bladder wall - Study involvement of SUFs in bladder diseases characterized by stiffness and fibrosis - Research Methods: - Use of conditional knockout mice - Advanced microscopy techniques - Gene expression profiling - Mechanotransduction studies - No commercial products, OEMs, or vendors are specified - No part numbers, product quantities, or procurement of goods/services involved - Unique Requirements: - Focused on scientific research, not acquisition of commercial items - Emphasis on advanced biological and molecular research techniques

Description

This NIH grant opportunity focuses on studying the role of fibroblasts in bladder mucosal function. The research aims to understand how suburothelial fibroblasts (SUFs) contribute to the viscoelastic properties of the bladder wall and their role in bladder diseases characterized by stiffness and fibrosis. The project will investigate the molecular mechanisms by which SUFs mediate contraction and influence bladder afferent signaling, using conditional knockout mice and advanced microscopy techniques. The study seeks to elucidate the physiological and pathological functions of bladder fibroblasts to inform potential therapeutic approaches.

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