NIH Reporter #1ZIADK032103-26

Award for HIV Neutralization Inhibitors Research and Development Project

This award notice from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) details a contract for advanced HIV research and development: - Government Buyer: - National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) - Part of the United States government - Scope of Work: - Research and development services focused on HIV neutralization inhibitors - Engineering and characterization of protein and small molecule therapeutics, probes, and vaccine immunogens for HIV/AIDS treatment and prevention - Includes work on carbohydrate-binding proteins, bispecific antibody chimeras, natural product inhibitors, peptide-based probes, and structural studies of HIV-1 Envelope-coreceptor interactions - Products/Services Requested: - Research and development services (1 lump sum) - Notable Requirements: - Emphasis on innovative engineering of therapeutic and diagnostic agents for HIV - No specific commercial products, part numbers, or OEMs identified in the notice - No OEMs or commercial vendors are named in the award announcement

Description

This project aims to identify and engineer protein and small molecule therapeutics, probes, and vaccine immunogens for the treatment and long-acting inhibition of HIV/AIDS. The research focuses on targeting the unique glycan shield of the HIV spike protein using engineered carbohydrate-binding proteins and bispecific antibody chimeras. Additional subprojects include discovering natural product inhibitors, peptide-based probes of HIV-1 cell entry, and studying HIV-1 Envelope-coreceptor interactions. The goal is to develop novel prevention and treatment strategies for HIV/AIDS, addressing challenges such as drug resistance and vaccine design.

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