NIH Reporter #5R35GM151249-03

NIH Research Grant Solicitation: OAS/RNase L Pathway in Viral Infections

This opportunity is a research grant solicitation from the National Institute of General Medical Sciences (NIGMS) at the National Institutes of Health (NIH) focused on the OAS/RNase L pathway during viral infections. - Government Buyer: - National Institutes of Health (NIH) - National Institute of General Medical Sciences (NIGMS) - No specific Original Equipment Manufacturers (OEMs) or commercial vendors are named in the solicitation - Products/Services Requested: - Research activities to investigate the OAS/RNase L pathway in the context of pathogenic viral infections - Key research areas include: - Mechanisms by which RNase L accelerates mRNA decay - Effects on translation reprogramming - Inhibition of nuclear mRNA export - Regulation of immune complexes - Viral evasion strategies - No specific products, part numbers, or purchase quantities are listed - Notable Requirements: - Open to research institutions and investigators with relevant expertise - Follows standard NIH grant application procedures - Estimated award value is $483,000 - No equipment or material procurement is specified; focus is on research outcomes

Description

This is a research grant opportunity from NIH for a project on the mechanisms and functions of the RNase L pathway during viral infections. The project aims to define how RNase L accelerates mRNA decay, reprograms translation, inhibits nuclear mRNA export, and regulates immune complexes, as well as how viruses evade these processes. The award amount is approximately $483,000 for the fiscal year 2025, with a project duration from September 15, 2023, to July 31, 2028.

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