NIH Reporter #5IK6BX004853-07

VA Solicitation for Research Services on Fatty Liver Disease and Therapeutic Development

This opportunity from the Omaha VA Medical Center seeks specialized research services to advance understanding and treatment of fatty liver disease in Veterans and military families. - Government Buyer: - Department of Veterans Affairs (VA) - Omaha VA Medical Center - Products/Services Requested: - Research services focused on alcoholic and non-alcoholic fatty liver disease (AFLD and NAFLD) - Emphasis on studying Golgi apparatus function and the small GTPase Rab3D in liver cell trafficking and injury - Identification of new therapeutic targets and strategies for disease progression - Expertise required in hepatocyte biology, alcohol-induced liver injury, and translational research - Unique/Notable Requirements: - No specific OEMs or commercial products are named; the solicitation is for advanced biomedical research services - Research must address both basic mechanisms and potential clinical applications for liver disease therapies - Focus on improving health outcomes for Veterans, military personnel, and their families

Description

This project focuses on addressing alcoholic and non-alcoholic fatty liver disease affecting Veterans, military personnel, and their families. The research aims to understand disease progression and develop therapeutic strategies by studying the role of Golgi apparatus function and the small GTPase Rab3D in liver cell trafficking and injury. The study investigates how ethanol exposure impairs Golgi apparatus function, affecting protein trafficking and secretion in hepatocytes, with the goal of identifying therapeutic targets to reduce liver injury. The project seeks to translate findings into therapies for fatty liver disease and broader hepatic conditions to improve healthcare for Veterans.

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