NIH Reporter #1R21AI197490-01

Construction of Water and Sewer Lines at University of Utah (NIAID)

This opportunity involves the construction of water and sewer lines at the University of Utah, Salt Lake City, under the National Institute of Allergy and Infectious Diseases (NIAID): - Government Buyer: - National Institute of Allergy and Infectious Diseases (NIAID), part of the Utah State Higher Education System - OEMs and Vendors: - ABC Construction (vendor) - Products/Services Requested: - Construction of water and sewer lines - Quantity: 1,000 linear feet - NAICS code: 237110 (Water and Sewer Line and Related Structures Construction) - Unique or Notable Requirements: - Compliance with licensing as specified in the solicitation - Project is associated with Schools of Medicine - Project scope document is available for further details - Funded amount: $423,500 - Award and solicitation are both announced for this project

Description

This project focuses on investigating the role of cholesterol metabolism in regulatory T cell (Treg) function, particularly in the context of autoimmunity. The research aims to test the hypothesis that cholesterol metabolism, regulated by the transcription factor Foxp3, can be manipulated to enhance Treg function. Two specific aims include studying the role of the regulator Spring1 in Treg function and assessing the impact of exogenous cholesterol uptake on Treg suppressive function. The findings could have implications for autoimmune, inflammatory, cancer, metabolic, and heart diseases.

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