NIH Reporter #5F31HL178291-02

Research Grant: mTOR Inhibitors and Vascular Barrier Dysfunction Study

This opportunity is a research grant solicitation from the National Heart Lung and Blood Institute (NHLBI) in collaboration with the University of Maryland, College Park's Department of Biomedical Engineering. - Government Buyer: - National Heart Lung and Blood Institute (NHLBI) - University of Maryland, College Park, Department of Biomedical Engineering - Products/Services Requested: - Research services to study the effects of mTOR inhibitors (targeting mTORC1 and mTORC2) on endothelial cell-to-cell junctions and vascular barrier dysfunction - Analysis of how mTORC1 and mTORC2 inhibition impacts endothelial barrier integrity and dynamics - OEMs and Vendors: - No specific OEMs or vendors are named; opportunity is open to qualified research entities - Unique/Notable Requirements: - Focus on mTOR pathway and vascular biology - Project classified under CFDA code 93.837 (Blood and Blood Forming Organs) - No unique license or classification requirements specified - Estimated grant value is $18,988

Description

This is a research grant opportunity from the NIH for a project investigating the effects of mTOR inhibitors on endothelial cell junctions and vascular permeability. The project aims to analyze how inhibiting mTORC1 and mTORC2 affects endothelial barrier integrity and dynamics. The research is focused on understanding vascular barrier dysfunction through the study of endothelial cell-to-cell junction dynamics.

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