NIH Reporter #3R00HL157552-05S1

NIH Solicitation: siRNA Nanoparticle Therapeutic Development for Kidney Transplant Injury

This opportunity from the National Heart Lung and Blood Institute (NHLBI) at the National Institutes of Health (NIH) seeks proposals for a research project targeting kidney ischemia reperfusion injury. - Government Buyer: - National Institutes of Health (NIH), National Heart Lung and Blood Institute (NHLBI) - OEMs and Vendors: - No specific OEMs or vendors are named in the solicitation - Products/Services Requested: - Development of a therapeutic strategy using polymeric nanoparticles for targeted siRNA delivery to endothelial cells - Focus on reducing ischemia reperfusion injury-related damage in transplanted kidneys - No specific products, part numbers, or purchase quantities are listed - Unique or Notable Requirements: - Expertise in siRNA delivery and polymeric nanoparticle technology - Experience in therapeutic development for vascular inflammation and kidney transplantation - Project to be performed at Villanova University, PA - Estimated contract value: $58,434

Description

This project aims to develop a multi-faceted therapeutic strategy to reduce ischemia reperfusion injury related damage to the endothelium of transplanted kidneys. The project involves the use of polymeric nanoparticles for targeted siRNA delivery to endothelial cells, with potential applications in kidney transplantation and vascular inflammation. The project is funded by NIH and has a budget of USD 58,434 for the fiscal year 2024. The project start date is September 1, 2024, and end date is August 31, 2026.

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