NIH Reporter #1R21AI190832-01

Research Award for Sapovirus Immunity Studies in Children

This opportunity involves a research award from the National Institute of Allergy and Infectious Diseases (NIAID) to the University of North Carolina at Chapel Hill, School of Medicine, focused on sapovirus immunity in children. - Government Buyer: - National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health - Awardee: - University of North Carolina at Chapel Hill, School of Medicine - Products/Services Requested: - Research and development services for neutralization assay development - Application of assays to biobanked samples from a birth cohort (n=444) and longitudinal samples from children in Nicaragua - OEMs and Vendors: - No specific OEMs or commercial vendors are mentioned; the work is performed by the university - Notable Requirements: - Expertise in propagating sapovirus (SaV) - Access to and use of biobanked samples from relevant pediatric cohorts - Focus on understanding natural humoral immunity to sapovirus, a leading cause of acute gastroenteritis in children - No commercial products, part numbers, or equipment specified; the procurement is for specialized research services

Description

This project aims to develop neutralization assays to better understand natural humoral immunity to sapovirus (SaV), a leading cause of acute gastroenteritis in children. The assays will be applied to biobanked samples from a birth cohort to answer fundamental questions about immunity. The research will characterize neutralizing antibody responses in children from Nicaragua using longitudinal serum and stool samples to aid vaccine development.

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