NIH Reporter #5F31HL172650-03

NHLBI Awards Research Project on Macrophage-Mediated Lung Repair to Harvard University

This opportunity involves the National Heart Lung and Blood Institute (NHLBI) funding a research project at Harvard University on lung repair mechanisms after viral injury. - Government Buyer: - National Heart Lung and Blood Institute (NHLBI), National Institutes of Health (NIH) - Awardee: - Harvard University - Products/Services Requested: - Research supplies (1 lot) - Laboratory equipment (1 each) - OEMs and Vendors: - No specific OEMs, brands, or part numbers are mentioned in the procurement - Project Focus: - Study of macrophage-mediated lung repair following viral respiratory injury - Use of a mouse-adapted influenza A virus model - Investigation of immune cell (macrophage) and epithelial cell communication - Notable Requirements: - Compliance with NIH research guidelines - Submission of proposals via the NIH grant portal - Award Amount: - $37,213 - Period of Performance: - Approximately three years

Description

This project focuses on understanding the role of immune cells, specifically macrophages, in lung tissue repair following viral respiratory infection. The study aims to define when and where macrophages are required for optimal epithelial repair and to elucidate the communication networks between macrophages and epithelial cells during lung regeneration. The research will use a mouse-adapted influenza A virus model to investigate these mechanisms. The goal is to identify molecular targets that could improve patient outcomes after viral infections.

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