NIH Reporter #1K22AG088111-01

NIH NIA Grant: Research on Molecular Determinants of Age-Related Cognitive Decline

This opportunity is a grant solicitation from the National Institute on Aging (NIA), part of the NIH, focused on research into the molecular determinants of age-related cognitive decline. - Government Buyer: - National Institute on Aging (NIA), National Institutes of Health (NIH) - OEMs and Vendors: - No specific OEMs or vendors are named in the solicitation - Products/Services Requested: - Research services in neuroscience - Focus on transcriptomics, microscopy, and behavioral assays - Study of molecular mechanisms underlying cognitive decline in the basal forebrain to lateral entorhinal cortex circuit - Identification of molecular signatures of vulnerability in neural circuits related to aging and neurodegenerative diseases (e.g., Alzheimer's) - Unique/Notable Requirements: - Emphasis on advancing scientific understanding of age-related cognitive decline - No specific products, part numbers, or purchase quantities listed - Open to research institutions with relevant expertise - Estimated contract value: $198,352 - No product line items; primary service is research

Description

This grant opportunity seeks to identify molecular signatures of vulnerability in the circuit between basal forebrain cholinergic neurons and the lateral entorhinal cortex, focusing on aging and neurodegenerative conditions such as Alzheimer's disease. The project involves the use of transcriptomics, microscopy, and behavioral assays to understand the circuit mechanisms underlying age-related cognitive decline. The award is for the fiscal year 2026, with a project duration from March 15, 2026, to February 28, 2029.

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