NIH Reporter #5F31DK139684-02

NIH Award for Research on Hemopexin's Role in Urologic Chronic Pelvic Pain Syndrome

This award notice from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health, recognizes a research project at the University of Alabama at Birmingham. - Government Buyer: - National Institutes of Health (NIH) - National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) - Awardee: - University of Alabama at Birmingham - Project Focus: - Research on the role of hemopexin in the development of urologic chronic pelvic pain syndrome (UCPPS) - Investigates the relationship between chronic stress, hemopexin depletion, and UCPPS symptomatology - Utilizes behavioral assessments, electrophysiology, and brain imaging in female mice - Explores anti-inflammatory effects of hemopexin via heme scavenging and its impact on pelvic and visceral pain - Products/Services Requested: - No specific products, OEMs, or purchase quantities are mentioned - Primary service is scientific research - Unique Requirements: - Focus on animal model research (female mice) - Emphasis on understanding biochemical and neurological mechanisms underlying chronic pelvic pain - OEMs and Vendors: - No OEMs or commercial vendors referenced in the notice - Estimated Contract Value: - $41,696

Description

This research project investigates the role of hemopexin in the development of urologic chronic pelvic pain syndrome (UCPPS). It focuses on the relationship between chronic stress, hemopexin depletion, and UCPPS symptomatology using behavioral assessments, electrophysiology, and brain imaging in female mice. The study aims to understand the anti-inflammatory effects of hemopexin through heme scavenging and its impact on pelvic and visceral pain. The research is conducted at the University of Alabama at Birmingham and supported by NIH funding.

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