NIH Reporter #5R01DE031476-05

NIH Grant for Personalized Periodontal Tissue Regeneration Biofabrication Research

This opportunity involves a grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the National Institutes of Health, to the University of Michigan at Ann Arbor for advanced periodontal tissue regeneration research. - Government Buyer: - National Institutes of Health (NIH) - National Institute of Dental and Craniofacial Research (NIDCR) - Awardee: - University of Michigan at Ann Arbor - Products/Services Requested: - Research and development of personalized, compositionally graded, and structurally tailored scaffolds for periodontal tissue regeneration - Focus on polymeric and multi-material scaffolds to support bone growth and guide periodontal ligament formation - Efficacy testing in animal models - Unique/Notable Requirements: - Emphasis on converged biofabrication approaches for personalized medicine - Addresses tissue destruction from gum disease - Classified under NAICS codes 237110 (Water and Sewer Line and Related Structures Construction) and 541330 (Engineering Services) - No specific OEMs, vendors, part numbers, or product quantities are mentioned in the opportunity.

Description

This NIH grant opportunity aims to develop personalized biofabrication approaches to create scaffolds for periodontal tissue regeneration. The project focuses on engineering compositionally graded and structurally tailored scaffolds to support bone growth and guide periodontal ligament formation, addressing tissue destruction caused by gum disease. The research includes optimizing polymeric scaffolds for moderate defects and developing multi-material scaffolds for minimal surrounding bone defects, with efficacy tested in animal models. The goal is to translate personalized therapies to prevent tooth loss due to periodontitis.

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