NIH Reporter #PA-20-185

Cardiovascular Health Assessments, Carotid Ultrasonography, and DNA Methylation Analysis for HAPO Offspring

This opportunity from the National Heart Lung and Blood Institute seeks specialized research services for the Hyperglycemia and Adverse Pregnancy Outcome Study-Cardiovascular Health of HAPO Offspring (HAPO CVH). - Government Buyer: - National Heart Lung and Blood Institute (NHLBI) - Scope of Work: - Cardiovascular health assessments for 1,000 HAPO offspring - Carotid ultrasonography for 1,000 subjects - DNA methylation analysis (epigenetic testing) for 1,000 subjects - Products/Services Requested: - Cardiovascular health assessment (1,000 units) - Carotid ultrasonography (1,000 units) - DNA methylation analysis (1,000 units) - Unique Requirements: - Comprehensive evaluation of blood pressure, lipid profiles, and epigenetic mechanisms - Focus on intrauterine exposures and their impact on later health outcomes - Use of HAPO study cohort data - OEMs and Vendors: - No specific OEMs or part numbers are mentioned - Lurie Children's Hospital of Chicago is noted as a prospective bidder - Notable Details: - Emphasis on advanced epigenetic analysis and cardiovascular imaging - Open, negotiated solicitation

Description

This is a research grant opportunity from the NIH focused on projects related to nephronophthisis-related ciliopathies and ciliary specialization. The research aims to explore molecular mechanisms, remodeling, and extracellular vesicle biogenesis in model organisms such as C. elegans. The grant supports studies in cystic kidney diseases and related biological processes. No specific line items or bid schedule are provided.

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