NIH Reporter #5IK6BX006184-04

Research Grant Solicitation for DNase Inhibitor Development for Organ Injury

This opportunity is a research grant solicitation from the Central Arkansas Veterans Healthcare System (part of the Department of Veterans Affairs) for the BLRD Research Career Scientist Award. - Government Buyer: - Department of Veterans Affairs (VA) - Central Arkansas Veterans Healthcare System - Research Focus: - Study of DNases (enzymes responsible for DNA fragmentation) in organ or tissue injury - Identification of endonucleases involved in DNA fragmentation in kidney, liver, and cancer cells - Development of non-toxic endonuclease inhibitors as universal cytoprotective drugs - Targeted Health Conditions: - Organ or tissue injury due to poisoning, radiation, hypoxia, cancer, or atherosclerosis - Acute organ injuries among Veterans, military personnel, and the elderly - Unique Requirements: - Expertise in cytotoxic DNases - Development of universal, non-toxic protective agents for organ injuries - No specific OEMs, vendors, or commercial products are mentioned - No product or service line items or purchase quantities are listed

Description

This NIH grant opportunity focuses on studying DNases, enzymes that fragment DNA during organ or tissue injury caused by factors such as poisoning, radiation, hypoxia, cancer, or atherosclerosis. The research aims to understand DNA fragmentation mechanisms and develop inhibitors that could serve as universal drugs to treat human diseases including cancer and organ injuries. The project is highly relevant to Veterans Affairs healthcare due to the prevalence of organ injuries among Veterans, military personnel, and the elderly. The goal is to create protective agents for acute organ injuries applicable during military operations and clinical settings.

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