NIH Reporter #5F31AI191669-02

NIAID Research Project: Mechanisms of SARS-CoV-2 BST2 Antagonism and Antiviral Development

This opportunity involves a research project funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), focused on understanding how SARS-CoV-2 evades the antiviral factor BST2. - Government Buyer: - National Institutes of Health (NIH) - National Institute of Allergy and Infectious Diseases (NIAID) - Project Scope: - Research on the mechanisms by which SARS-CoV-2 antagonizes BST2 - Focus on the role of Spike protein mutations in immune evasion - Assessment of the impact on antibody-mediated immune responses - Development of antiviral strategies to block SARS-CoV-2 evasion - Technical Approach: - Utilizes molecular biology, immunology, and virology techniques - Products/Services Requested: - No specific commercial products, OEMs, or part numbers are mentioned - Primary service is scientific research and development in virology and immunology - Unique Requirements: - Emphasis on mechanistic understanding of viral immune evasion - Goal to inform antiviral development targeting SARS-CoV-2's evasion of BST2

Description

This project aims to investigate the mechanisms and implications of SARS-CoV-2 antagonism of the cellular antiviral factor BST2. The study will explore how mutations in the Spike protein enhance the virus's ability to evade BST2, which restricts enveloped viruses by tethering virions to the cell surface and facilitating immune recognition. The research will elucidate the mechanism of BST2 evasion, assess its impact on antibody-mediated responses, and develop antivirals to block SARS-CoV-2's evasion strategies.

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