SAM #75N98026Q00800

NIH OLAO Requests Olink Explorer >5400 Protein Analysis Platform for High-Throughput Protein Measurement

The National Institutes of Health Office of Logistics and Acquisition Operations (NIH OLAO), under the Department of Health and Human Services, is seeking to procure a high-throughput protein analysis platform. - Government Buyer: - National Institutes of Health (NIH) - Office of Logistics and Acquisition Operations (OLAO) - OEM Highlight: - Olink is the specified manufacturer of the requested platform - Product/Service Requested: - Olink Explorer >5400 Protein Analysis Platform - Measures over 5,400 human proteins simultaneously - Utilizes Proximity Extension Assay (PEA) technology with dual antibody recognition and DNA barcoding - Employs next-generation sequencing (NGS) for readout - Requires only 2 µl of plasma, serum, or other sample types - Offers 99.5% specificity and negligible cross-reactivity - Provides a dynamic range of approximately 10 orders of magnitude - Highly standardized for epidemiology and multi-omics studies - Notable Requirements: - No specific part numbers or purchase quantities provided - Emphasis on high specificity, minimal sample volume, and suitability for large-scale studies

Description

Requirements:

2.0       BACKGROUND 

Our lab studies the role of inflammation/innate resistance and commensal microbiota in carcinogenesis, cancer progression and therapy of cancer. 

The following product features/characteristics are required for this requirement:  

Protein Coverage - Measures ~5,400+ human proteins simultaneously in a single workflow. 

Technology - Uses Proximity Extension Assay (PEA) with dual antibody recognition coupled to DNA barcoding and next-generation sequencing (NGS) readout. 

Sample input – requires only 2 ul of plasma, serum, and other sample types 

Specificity - Reported 99.5% specificity with negligible cross-reactivity due to dual-recognition antibody design. 

Dynamic Range - Approximately 10 orders of magnitude (fg/mL to mg/mL), enabling detection of both low- and high-abundance proteins. 

Key strengths 

Very broad proteome coverage while maintaining antibody-based specificity.  

Excellent sensitivity for low-abundance circulating proteins (especially cytokines and signaling proteins).  

Extremely low sample-volume requirement.  

Highly standardized platform, making it attractive for epidemiology and multi-omics studies.

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