NIH Reporter #4RF1AG078340-02

Research and Development of Animal Model for Early Alzheimer’s Disease Pathogenesis

This opportunity is issued by the National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services. - The NIA seeks proposals for research and development of an animal model for early Alzheimer’s disease (AD) pathogenesis. - Focus is on the interoceptive-allostatic network, using rhesus monkeys as the animal model. - Research will investigate the effects of amyloid beta oligomers (AβOs) on neural hubs involved in affect regulation. - The goal is to understand mechanisms of affective and cognitive decline in AD and to test interventions that may prevent disease progression. - No specific Original Equipment Manufacturers (OEMs), vendors, or commercial products are named in the solicitation. - The work will require expertise in neuroimaging, histological analysis, and behavioral studies. - No part numbers, product line items, or specific purchase quantities are provided. - Unique requirements include the use of nonhuman primates (rhesus monkeys) and a focus on early-stage AD mechanisms within the interoceptive-allostatic network.

Description

This project aims to develop an animal model of early Alzheimer’s disease pathogenesis focusing on the interoceptive-allostatic network. The research involves investigating how amyloid beta oligomers generate structural, cellular, and synaptic pathology in neural hubs responsible for affect regulation, using rhesus monkeys as a model. The study builds on previous work demonstrating that amyloid beta oligomers cause synapse loss and neuroinflammation, mirroring early human Alzheimer’s disease pathology. The goal is to understand mechanisms of affective and cognitive decline in Alzheimer’s disease and to test interventions that could prevent disease progression.

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