NIH Reporter #4R01AI170725-04

NIAID Research Grant: Hepatic Antiviral T Cell Response During Hepacivirus Infection

This opportunity is a research grant solicitation from the National Institute of Allergy and Infectious Diseases (NIAID) focused on hepatic antiviral T cell responses during hepacivirus infection. - Government Buyer: - National Institutes of Health (NIH) - National Institute of Allergy and Infectious Diseases (NIAID) - Project Objective: - Investigate the functional diversity and roles of hepatic T cell subsets (CD4+, CD8+, NKT cells) in antiviral immunity and liver disease progression - Utilize an immune-competent mouse model of Norway rat hepacivirus (NrHV) - Employ high-dimensional flow cytometry, in vivo functional approaches, and transcriptome analysis - Intended Outcomes: - Inform vaccine strategies and immunotherapeutic options for hepatitis C virus (HCV) and related liver diseases - Notable Requirements: - No specific OEMs, vendors, or commercial products are mentioned - Research must translate findings to human HCV patients - No product part numbers or purchase quantities are provided

Description

This NIH grant opportunity seeks research into the functional diversity of hepatic antiviral T cell responses during hepacivirus infection using an immune-competent mouse model. The project aims to elucidate the roles of different T cell subsets, including CD4+, CD8+, and natural killer T cells, in antiviral immunity and liver disease progression. The study will employ high-dimensional flow cytometry, in vivo functional approaches, and transcriptome analysis to understand immune mechanisms and translate findings to human hepatitis C virus patients. The research supports the development of vaccine strategies and immunotherapeutic options for liver diseases.

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